[HTML][HTML] What's that (blue) spot on my MRI? Multimodal neuroimaging of the locus coeruleus in neurodegenerative disease

M Kelberman, S Keilholz, D Weinshenker - Frontiers in neuroscience, 2020 - frontiersin.org
The locus coeruleus (LC) has long been underappreciated for its role in the pathophysiology
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …

[HTML][HTML] Locus coeruleus magnetic resonance imaging in neurological diseases

A Galgani, F Lombardo, D Della Latta, N Martini… - Current Neurology and …, 2021 - Springer
Abstract Purpose of Review Locus coeruleus (LC) is the main noradrenergic nucleus of the
brain, and its degeneration is considered to be key in the pathogenesis of …

[HTML][HTML] Locus Coeruleus magnetic resonance imaging: a comparison between native-space and template-space approach

FS Giorgi, N Martini, F Lombardo, A Galgani… - Journal of Neural …, 2022 - Springer
Locus Coeruleus (LC) is the main noradrenergic nucleus of the brain, which is involved in
many physiological functions including cognition; its impairment may be crucial in the …

What are current concepts on the functional organization of the locus coeruleus and its role in cognition and neurodegeneration?

E Benarroch - Neurology, 2023 - AAN Enterprises
The locus coeruleus noradrenergic (LC-NE) system provides a widespread innervation to
the CNS. Through both targeted and diffuse projections, this system has a major role in the …

Magnetic resonance imaging of the human locus coeruleus: A systematic review

KY Liu, F Marijatta, D Hämmerer… - Neuroscience & …, 2017 - Elsevier
The locus coeruleus (LC), the major origin of noradrenergic modulation of the central
nervous system, innervates extensive areas throughout the brain and is implicated in a …

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

MJ Betts, E Kirilina, MCG Otaduy, D Ivanov… - Brain, 2019 - academic.oup.com
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

[HTML][HTML] Exploring the role of Locus Coeruleus in Alzheimer's Disease: a Comprehensive Update on MRI studies and implications

A Galgani, FS Giorgi - Current Neurology and Neuroscience Reports, 2023 - Springer
Abstract Purpose of Review Performing a thorough review of magnetic resonance imaging
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …

Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia

A Galgani, F Lombardo, N Martini… - European Journal of …, 2023 - Wiley Online Library
Background and purpose Human neuropathological studies indicate that the pontine
nucleus Locus Coeruleus (LC) undergoes significant and early degeneration in Alzheimer's …

[HTML][HTML] In vivo visualization of the locus coeruleus in humans: quantifying the test–retest reliability

KD Tona, MC Keuken, M de Rover, E Lakke… - Brain Structure and …, 2017 - Springer
The locus coeruleus (LC) is a brainstem nucleus involved in important cognitive functions.
Recent developments in neuroimaging methods and scanning protocols have made it …

[HTML][HTML] In vivo visualization of age-related differences in the locus coeruleus

KY Liu, J Acosta-Cabronero, A Cardenas-Blanco… - Neurobiology of …, 2019 - Elsevier
The locus coeruleus (LC), the major origin of noradrenergic modulation of the central
nervous system, may play an important role in neuropsychiatric disorders including …