Lipids in skeletal muscle play a fundamental role both in normal muscle metabolism and in
disease states. Skeletal muscle lipid accumulation is associated with several chronic …

Background Elevated fatty acids contribute to the development of type 2 diabetes and affect
skeletal muscle insulin sensitivity. Since elevated intramuscular lipids and insulin resistance …

Although it is clear that lipids are responsible for insulin resistance, it is poorly understood
what types of lipids are involved. In this study, we verified the characteristic lipid species in …

We compare comprehensive quantitative profiling of lipids at the molecular level from
skeletal muscle tissues (gastrocnemius and soleus) of Zucker diabetic fatty rats and Zucker …

Lipid mediators (LMs) are a class of bioactive metabolites of the essential polyunsaturated
fatty acids (PUFA), which are involved in many physiological processes. Their quantification …

Muscle atrophy refers to skeletal muscle loss and dysfunction that affects glucose and lipid
metabolism. Moreover, muscle atrophy is manifested in cancer, diabetes, and obesity. In this …

Skeletal muscles are composed of heterogeneous muscle fibers that have different
physiological, morphological, biochemical, and histological characteristics. In this work …

Diacylglycerol (DAG) is an intermediate lipid involved in the synthesis of phospholipids and
triglycerides. As signaling regulators, DAG activate novel protein kinase C leading to …

Background Skeletal muscle lipid is associated with obesity and type 2 diabetes and may be
altered by diet, physical activity, and weight loss. Objective We explored the utility of …

Skeletal muscle lipid accumulation is associated with several chronic metabolic disorders,
including obesity, insulin resistance (IR) and type 2 diabetes. The aim of this study is to …