Objective To investigate whether differences in muscle fiber types affect early-stage fat
accumulation, under high fat diet challenge in mice. Methods Twelve healthy male C57BL/6 …

It is well described that increasing free fatty acids (FFAs) to high physiological levels reduces
insulin sensitivity. In sedentary humans, intramyocellular lipid (IMCL) is inversely related to …

Endurance training enhances the capacity for fat oxidation during exercise due to increased
utilization of intramuscular lipid (IMCL). This study quantitatively investigated the impact of …

The effect of short-term fat loading on intramyocellular lipid (IMCL) in different types of
muscle in endurance runners and sprinters has not been fully elucidated yet. The purpose of …

The phenotype of sarcopenic obesity is frequently associated with impaired muscle strength
and performance. Ectopic lipid deposition may interfere with muscle anabolic response …

Fatty acids are stored within the muscle as intramyocellular lipids (IMCL). Some, but not all,
studies indicate that following a high-fat diet (HFD), IMCL may accumulate and affect insulin …

Background: Ectopic fat accumulation in skeletal muscle results in dysfunction and atrophy,
but the underlying molecular mechanisms remain unclear. Objective: The aim of this study …

A high-saturated-fat diet (HFD) induces obesity and insulin resistance (IR). IR has been
linked to alterations and increased saturation in the phospholipid composition of skeletal …

Background: Fat deposition in muscle has been found to be related to metabolic risk.
Objective: This study compared soleus intramyocellular lipid (IMCL) concentrations after …

In obesity, accumulation of lipid droplets in skeletal muscle fibers and a shift towards fast
muscle fiber types can both contribute to insulin resistance. However, it is not yet clear how …