Introduction Uterine cervical cancer (UCC) is the fourth most common health problem
worldwide among women. Currently available biomarkers CA125, CA199, and CEA for …

In spite of the effective implementation of screening programs, uterine cervical carcinoma
(UCC) remains one of the major causes of cancer death among women around the world …

Background: To date, no good marker for screening or disease monitoring of endometrial
cancer (EC) is available. The aims of this study were to investigate HE4 gene, protein …

Background: HE4 may be a valuable early indicator of the recurrence of gynecologic
cancers. Numerous studies have shown that high expression levels of serum HE4 correlate …

Background To evaluate the prognostic impact of HE4 expression in patients with cancer.
Materials and methods We searched the PubMed, Web of Science, Chinese National …

Objective To evaluate the value of individual and combined measurement of human
epididymis protein 4 (HE4) and cancer antigen 125 (CA-125) in the diagnosis of ovarian …

Purpose In this study, the prognostic value of serum HE4 was investigated in patients with
advanced ovarian, fallopian tube, and peritoneal carcinoma. Methods Serum HE4 and …

The HE4 protein, which belongs to the “four disulfide” acid protein group, has emerged as
one of the most promising biomarkers in gynecologic oncology. An expert meeting on the …

Background: Human epididymis protein 4 (HE4) protein has garnered a great degree of
interest as a complementary biomarker to carbohydrate antigen 125 (CA125), or even as an …

Purpose To explore the clinical value of the level of human epididymis protein 4 (HE4) in
serum in the diagnosis, prediction of postoperative recurrence and prognosis of epithelial …