Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central
nervous system disorders. Like mural cells, PVFs surround blood vessels and express …

The blood-brain barrier is essential for the proper homeostasis and function of the CNS, but
its mechanism of function is poorly understood. Perivascular cells surrounding brain blood …

The establishment of a fully functional blood vascular system requires elaborate angiogenic
and vascular maturation events in order to fulfill organ-specific anatomical and physiological …

Background The microvasculature is the network of blood vessels involved in delivering
nutrients and gases necessary for tissue survival. Study of the microvasculature often …

Pericytes, the mural cells of blood microvessels, regulate microvascular development and
function and have been implicated in many brain diseases. However, due to a paucity of …

Ex vivo 2-photon fluorescence microscopy (2PFM) with optical clearing enables vascular
imaging deep into tissue. However, optical clearing may also produce spherical aberrations …

Pericytes regulate key neurovascular functions of the brain. Studies in pericyte-deficient
transgenic mice with aberrant signaling between endothelial-derived platelet-derived growth …

Perivascular cells expressing platelet-derived growth factor receptor beta (PDGFR-β) have
recently been implicated in fibrotic scar formation after acute brain injury, but their precise …

INTRODUCTION Brain homeostasis depends on adequate levels of blood flow to ensure the
delivery of nutrients and to facilitate the removal of catabolic products. The exchange of …

Blood vessels and adjacent cells form perivascular stem cell niches in adult tissues. In this
perivascular niche, a stem cell with mesenchymal characteristics was recently identified in …