Emotional stress is considered a severe pathogenetic factor of psychiatric disorders.
However, the circuit mechanisms remain largely unclear. Using a three-chamber vicarious …

Background Animal models capable of differentiating the neurobiological intricacies
between physical and emotional stress are scarce. Current models rely primarily on physical …

Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet
unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone …

Dopamine neurons in the ventral tegmental area (VTA) are powerful regulators of
depression-related behavior. Dopamine neuron activity is altered in chronic stress-based …

Chronic social defeat stress (CSDS) is a clinically relevant model of mood disorders. The
relationship between the CSDS model and a physiologically pertinent paradigm of synaptic …

Numerous studies have employed repeated social defeat stress (RSDS) to study the
neurobiological mechanisms of depression in rodents. An important limitation of RSDS …

Background The nucleus accumbens is a critical mediator of depression-related outcomes
to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in …

Although cerebellar alterations have been implicated in stress symptoms, the exact
contribution of the cerebellum to stress symptoms remains to be elucidated. Here, we …

Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress
susceptibility and resilience. However, upstream mechanisms controlling these neurons …

Psychological stress contributes to the onset and exacerbation of nearly all neuropsychiatric
disorders. Individual differences in stress-regulatory circuits can therefore dramatically affect …