Simple Summary Colorectal cancer is one of the leading causes of global cancer-related
mortality. Tumor-infiltrating effector immune cells play critical roles in tumor control, and their …

The existence of various T regulatory cell (Treg) subsets in colorectal cancer (CRC) could
play a variety of functions in the regulation of anti-cancer immunity. We studied correlations …

There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the
regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a …

Blockade of inhibitory immune checkpoints (ICs) is a promising therapeutic approach;
however, it has shown limited success in some cancers including colorectal cancer (CRC) …

T regulatory cells (Tregs) play different roles in the regulation of anti-tumor immunity in
colorectal cancer (CRC), depending on the presence of different Treg subsets. We …

Immune checkpoints (ICs) are highly expressed on tumor-infiltrating immune cells (TIICs) in
different malignancies, including colorectal cancer (CRC). T cells play crucial roles in …

Colorectal cancer (CRC) is one of the most prevalent cancer types worldwide, with a high
mortality rate due to metastasis. The tumor microenvironment (TME) contains multiple …

Despite recent advances in colorectal cancer (CRC) treatment, a large proportion of patients
show limited responses to therapies, especially in advanced stages. There is an urgent …

ABSTRACT T cells in colorectal cancer (CRC) are associated with improved survival.
However, checkpoint immunotherapies antagonizing the suppression of these cells are …

Background/Aim: Tumor microenvironments consist of many types of immune cells, in which
regulatory T-cells (Tregs) are supposed to play important roles to suppress anti-tumor …