Background There is indirect evidence that T cell responses can control the metastatic
spread of colorectal cancer (CRC). However, an enrichment of CD4+ Foxp3+ regulatory T …

AIM To investigate the abundance and potential functions of LAP+ CD4+ T cells in colorectal
cancer (CRC). METHODS Proportions of LAP+ CD4+ T cells were examined in peripheral …

Background The prognostic value of intratumor T regulatory cells (Tregs) in colorectal
cancer (CRC) was previously reported, but the role of these cells in tumor draining lymph …

Activated T regulatory (Treg) cells are potent suppressors that mediate immune tolerance.
We investigated the relationship between activated Treg cells and the progression of human …

T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an inhibitory immune
checkpoint, which suppresses anti-tumor immune responses. TIM-3 expression on different …

Background Current stratification systems for tumor prognostic prediction and
immunotherapeutic efficacy evaluation are less satisfying in colorectal cancer (CRC). As …

Background/Aim: The limited efficacy of immune checkpoint inhibitors in colorectal cancer
(CRC) is likely due to immunosuppressive mechanisms including T cell exhaustion caused …

Regulatory T (Treg) cells are critical suppressors of inflammation and are thought to exert
mainly deleterious effects in cancers. In colorectal cancer (CRC), Foxp3+ Treg accumulation …

Purpose: To assess the relation of Foxp3+ regulatory T cells (Treg) in tumor draining lymph
nodes (TDLNs) with tumor progression and immune suppression in colorectal cancer …

The human immune system consists of a balance between immune surveillance against non-
self antigens and tolerance of self-antigens. CD8+ T cells and CD4+ regulatory T cells …