Abstract Background Regulatory T cells (Tregs) play an important role in regulation of
immune response and immunologic tolerance in cancer. Gastrointestinal cancer is still a …

Background: Colorectal cancer is considered the third most prevalent cancer in both sexes.
Immune checkpoint receptors that regulate T-cell response, stimulation, and development …

Background: The antitumoral immune response is one determinant of colorectal cancer
(CRC) outcome. Recent work suggests that Foxp3+ CD25+ CD4+ regulatory T cells (T4reg) …

Tumor microenvironment (TME) promotes immune suppression through recruiting and
expanding suppressive immune cells such as regulatory T cells (Tregs) to facilitate cancer …

Regulatory T cells represent a class of specialized T lymphocytes that suppress unwanted
immune responses and size the activation of the immune system whereby limiting collateral …

Tumor-infiltrating immune cells (TIICs) play essential roles in cancer development and
progression. However, the association of TIICs with prognosis in colorectal cancer (CRC) …

Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally,
in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling …

Regulatory T cells (Tregs) are a subset of CD4+ T lymphocytes known to dampen the host
immune response against cancer cells. Within the tumor microenvironment, Tregs are potent …

Objective This study aimed to characterize the tumor-infiltrating T cells in moderately
differentiated colorectal cancer. Methods Using single-cell RNA sequencing data of isolated …

Simple Summary Colorectal cancer is one of the deadliest cancers worldwide, with around
40% of patients dying from distant metastasis. Tumour immune cell infiltration has powerful …