Purpose High frequency of aneuploidy in meiosis and cleavage stage coincides with waves
of epigenetic genome reprogramming that may indicate a possible association between …

Early stages of human embryonic development are characterized by the spatiotemporal
coincidence of events of total epigenetic genome reprogramming and elevated level of …

Early stages of human embryonic development are characterized by spatio-temporal
coincidence of events of total epigenetic genome reprogramming and elevated level of …

The presence of an extra chromosome in the embryo karyotype often dramatically affects the
fate of pregnancy. Trisomy 16 is the most common aneuploidy in first-trimester miscarriages …

Miscarriage occurs in 15% of clinical pregnancies. Although chromosomal errors are
observed in> 50%, causes of karyotypically normal losses are poorly understood. DNA …

Background Series of epigenetic events happen during preimplantation development.
Therefore assistant reproduction techniques (ART) have the potential to disrupt epigenetic …

Background We analyzed placental DNA methylation levels at repeated sequences (LINE1
elements) and all CCGG sites (the LUMA assay) to study the effect of modifiable clinical or …

To study possible effects of assisted reproductive technologies (ART) on epigenetic
reprogramming, we have analyzed the DNA methylation levels of differentially methylated …

Dysregulation of transcriptional programs that are tightly regulated by DNA methylation
during placental and fetal development at different gestational stages, may cause recurrent …

LINE1 retrotransposons are mobile DNA elements that copy and paste themselves into new
sites in the genome. To ensure their evolutionary success, heritable new LINE-1 insertions …