Abstract Rationale: Kupffer cells (KCs) play a crucial role in liver immune homeostasis
through interacting with other immune cells and liver sinusoidal endothelial cells (LSECs) …

Leukocyte adhesion and transmigration are central features governing immune surveillance
and inflammatory reactions in body tissues. Within the liver sinusoids, chemokines initiate …

Background Chemokines contribute to the pathogenesis of autoimmune hepatitis by
directing the migration and positioning of inflammatory and immune cells within the liver …

We examined the in vivo behavior of liver natural killer T cells (NKT cells) by intravital
fluorescence microscopic imaging of mice in which a green fluorescent protein cDNA was …

Chronic liver injury characteristically results in hepatic inflammation, which represents a
prerequisite for organ fibrosis. Although NKT cells are abundantly present in liver and …

The role played by chemokines in regulating the selective recruitment of lymphocytes to
different tissue compartments in disease is poorly characterized. In hepatitis C infection …

The liver contains macrophages and myeloid dendritic cells (mDCs) that are critical for the
regulation of hepatic inflammation. Most hepatic macrophages and mDCs are derived from …

Liver sinusoidal endothelial cells (LSECs) rapidly clear lipopolysaccharide (LPS) from the
bloodstream and establish intimate contact with immune cells. However, their role in …

Background & Aims The gut microbiota significantly influences hepatic immunity. Little is
known on the precise mechanism by which liver cells mediate recognition of gut microbes at …

Liver monocytes play a major role in the development of NASH (non-alcoholic
steatohepatitis). In inflamed tissues, monocytes can differentiate in both macrophages and …