Life on Earth is dictated by circadian changes (eg, sunlight, temperature, and humidity) in
the environment caused by the planet's rotation around its own axis. All forms of life have …

Pharmacokinetics deals with the in vivo fate of or disposition processes of the drug (ie how
the body does to the drug) that determine drug exposure and therefore pharmacological …

Most mammalian physiology is orchestrated by the circadian clock, including drug transport
and metabolism. As a result, efficacy and toxicity of many drugs are influenced by the timing …

Dependence of pharmacokinetics and drug effects (efficacy and toxicity) on dosing time has
long been recognized. However, significant progress has only recently been made in our …

In recent years, the relevance of the circadian clock in physiology, pathology and
therapeutics has increased exponentially, as evidenced by the 2017 Nobel Prize in …

Dosing time accounts for a large variability in efficacy and/or toxicity for many drugs.
Therefore, chronotherapy has been shown to effectively improve drug efficacy and to reduce …

Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …

Circadian rhythms are ubiquitous phenomena that recur daily in a self-sustaining,
entrainable, and oscillatory manner, and orchestrate a wide range of molecular …

A rough 24-hour cycle driven endogenously in biochemical, physiological or behavioral
processes is called circadian rhythm. Chronobiology is the study of biological temporal …

Drugs for several diseases are still given without regard to the time of the day. Variation in
dosing time is generally related with the effectiveness and toxicity of many drugs. On the …