OBJECTIVE: To mathematically assess drug losses due to infusion line residuals and
evaluate methods to compensate for drug loss due to residual volumes in intravenous pump …

The fundamental process of medication therapy is that a medication is ordered, verified, and
entirely administered to the patient. An unrecognized phenomenon across the antimicrobial …

This study examined the effect of various levels of renal impairment on the probability of
achieving free drug concentrations that exceed the MIC for 50% of the dosing interval (50% f …

Objectives: To evaluate the pharmacodynamic exposure of piperacillin/tazobactam across
the renal function range using 4.5 or 3.375 g dosing regimens. Methods: A 5000-patient …

Background For beta-lactams, the parameter that best predicts bacterial killing is the length
of time the antibiotic concentration exceeds the minimum inhibitory concentration (MIC) …

Objective: To perform a qualitative systematic review of the evidence comparing traditional
strategies against prolonged intermittent or continuous infusion strategies for piperacillin …

The introduction of a new protocol at Ghent University Hospital (Ghent, Belgium) for the
extended administration of piperacillin-tazobactam (TZP) and meropenem drew attention to …

BACKGROUND: Use of extended infusions of piperacillin/tazobactam (PT) in adult patients
has been described, but data in children are limited. OBJECTIVE: The goal of this study was …

Critically ill patients undergo significant pathophysiological changes that affect antibiotic
pharmacokinetics. Piperacillin/tazobactam administered by continuous infusion (CI) …

This prospective pharmacokinetic study aimed to compare the clearance of piperacillin-
tazobactam administered as a 24-h continuous infusion between continuous venovenous …