Airborne particulate matter induces oxidative damage, DNA adduct formation and alterations in DNA repair pathways

EM Quezada-Maldonado, Y Sánchez-Pérez… - Environmental …, 2021 - Elsevier
Air pollution, which includes particulate matter (PM), is classified in group 1 as a carcinogen
to humans by the International Agency for Research in Cancer. Specifically, PM exposure …

Oxidative stress-induced DNA damage by particulate air pollution

L Risom, P Møller, S Loft - Mutation Research/Fundamental and Molecular …, 2005 - Elsevier
Exposure to ambient air particulate matter (PM) is associated with pulmonary and
cardiovascular diseases and cancer. The mechanisms of PM-induced health effects are …

Oxidative stress and inflammation generated DNA damage by exposure to air pollution particles

P Møller, PH Danielsen, DG Karottki, K Jantzen… - … research/Reviews in …, 2014 - Elsevier
Generation of oxidatively damaged DNA by particulate matter (PM) is hypothesized to occur
via production of reactive oxygen species (ROS) and inflammation. We investigated this …

Effect of chemical composition on the induction of DNA damage by urban airborne particulate matter

ME Gutiérrez‐Castillo, DA Roubicek… - Environmental and …, 2006 - Wiley Online Library
Airborne particulate matter (PM) contains a large number of genotoxic substances capable
of endangering human health. In the present study, we have investigated the ability of …

DNA damage response of A549 cells treated with particulate matter (PM10) of urban air pollutants

Y Sánchez-Pérez, YI Chirino, ÁR Osornio-Vargas… - Cancer letters, 2009 - Elsevier
We describe the events triggered by a sub-lethal concentration of airborne particulate matter
(PM10) in A549 cells, which include the formation DNA double-strand breaks, γH2A. X …

Particulate matter inhibits DNA repair and enhances mutagenesis

M Mehta, LC Chen, T Gordon, W Rom… - Mutation Research/Genetic …, 2008 - Elsevier
Exposure to ambient air pollution has been associated with adverse health effects including
lung cancer. A recent epidemiology study has established that each 10μg/m3 elevation in …

Genotoxicity of airborne particulate matter: the role of cell–particle interaction and of substances with adduct-forming and oxidizing capacity

HL Karlsson, J Nygren, L Möller - Mutation Research/Genetic Toxicology …, 2004 - Elsevier
Exposure to particulate matter (PM) is associated with several health effects including lung
cancer. However, the mechanisms of particle-induced carcinogenesis are not fully …

Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways

RM Mroz, RPF Schins, H Li, LA Jimenez… - European …, 2008 - Eur Respiratory Soc
The epidemiological association between cancer and exposure to ambient air pollution
particles (particles with a 50% cut-off aerodynamic diameter of 10 μm (PM10)) has been …

Air pollution and cancer: biomarker studies in human populations

P Vineis, K Husgafvel-Pursiainen - Carcinogenesis, 2005 - academic.oup.com
Large cohort studies in the US and in Europe suggest that air pollution may increase lung
cancer risk. Biomarkers can be useful to understand the mechanisms and to characterize …

Effects of environmental air pollution on endogenous oxidative DNA damage in humans

R Singh, B Kaur, I Kalina, TA Popov… - Mutation Research …, 2007 - Elsevier
Epidemiological studies conducted in metropolitan areas have demonstrated that exposure
to environmental air pollution is associated with increases in mortality. Carcinogenic …