Inhaled nitric oxide (iNO) has many extrapulmonary effects. As the half-life of nitric oxide
(NO) in blood is orders of magnitude less than the circulation time from lungs to the brain …

OBJECTIVE: To measure the circulating concentrations of nitric oxide (NO) adducts with NO
bioactivity after inhaled NO (iNO) therapy in infants with pulmonary hypertension. STUDY …

Inhaled nitric oxide (iNO) enhances ventilation in very preterm infants, but the effects on the
brain remain uncertain. We evaluated the impact of iNO on brain growth and cerebral injury …

Pregnant sheep with a microdialysis probe implanted in the fetal cerebral cortex were used
to determine if nitrate and nitrite anions (nitrate/nitrite) could be quantitated in the …

Based upon studies of near-term fetal sheep, it was clear that inhaled NO was a selective
pulmonary vasodilator of the ovine perinatal pulmonary circulation. 2 We therefore treated …

Ventilation with nitric oxide (NO) is increasingly being used to treat pulmonary hypertension
in the newborn. In the brain, NO has vasoactive properties and is involved in …

Objective: Inhaled nitric oxide (iNO) is a potential new therapy for prevention of
bronchopulmonary dysplasia and brain injury in premature infants. This study examined …

To study the pulmonary vasodilator selectivity of low levels of inhaled nitric oxide (NO) in a
model of neonatal pulmonary hypertension, we sequentially exposed anesthetized …

The role of NO in the neonatal brain, particularly during hypoxia and ischaemia has been
studied extensively in animal models of focal and global ischaemia. The n-NOS and i-NOS …

Nitric oxide (NO) is a major regulator of vascular smooth muscle tone. Generated
enzymatically by one of several NO synthases from L-arginine, 1 NO activates guanylyl …