Chronic kidney disease (CKD) poses a formidable challenge for public healthcare
worldwide as vast majority of patients with CKD are also at risk of accelerated …

Oxidative stress and inflammation are important and critical mediators in the development
and progression of chronic kidney disease (CKD) and its complications. Shenkang injection …

Gentamicin is an aminoglycoside antibiotic that induces severe nephrotoxicity and acute
renal failure. In the current project, we investigated the protective effects of tissue kallikrein …

Aim: To investigate the effects of ROS scavenger N-acetylcysteine (NAC) on angiotensin II
(Ang II)-mediated renal fibrosis in vivo and in vitro. Methods: Mice were subjected to …

Renal ischemia/reperfusion-injury (IRI) is a common disease in clinic, which is also the most
common cause of acute kidney failure. Previous investigations has illustrated that catalpol …

Background: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease.
Impairment of kidney functions in RA was observed. However, the mechanism of kidney …

The kallikrein-kinin system (KKS) is a complex multi-enzyme system which is composed of
circulating and tissue kallikrein and kinin. It is well established that tissue kallikrein and kinin …

Emerging evidence suggests a role of the kallikrein-kinin system (KKS) in the pathogenesis
of diabetic nephropathy (DN). Tissue kallikrein 1 is a member of the tissue kallikrein family …

Background Activation of renal fibroblasts is a critical mechanism in the process of renal
fibrosis. As a commonly used herbal formula, Shenkang (SK) has been found to attenuate …

Tissue kallikrein (KLK1) expression is up-regulated in human diabetic kidney tissue and
induced by high glucose (HG) in human proximal tubular epithelial cells (PTEC). Since the …