Targeting multiple myeloma through protein kinase and ferroptosis therapeutics

E Logie - 2021 - repository.uantwerpen.be
Multiple myeloma (MM) is a B-cell malignancy characterized by the accumulation of a clone
of malignant plasma cells in the bone marrow. Despite recent advances in treatment …

P807: CLASS Ⅱ FERROPTOSIS INDUCERS ARE A NOVEL THERAPEUTIC APPROACH FOR T (4; 14)-POSITIVE MULTIPLE MYELOMA

J Zhang, Y Liu, L Zuo, F Fan, H Yan, F Zhao… - …, 2023 - journals.lww.com
Background: Multiple myeloma (MM) is characterized by genetic heterogeneity. The
cytogenetic abnormality t (4; 14) strongly predicts poor outcomes in MM patients. MM SET …

Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications

D Chauhan, KC Anderson - Apoptosis, 2003 - Springer
Multiple myeloma (MM), a hematologic malignancy, remains fatal despite all available
therapies. Initial treatment with conventional drugs effectively induces MM cell …

Integrative analysis of enrichment and prognostic value of ferroptosis-related genes and pathways in multiple myeloma

Q Su, Q Li, W Zhang, B Li, W Zhuang - Carcinogenesis, 2022 - academic.oup.com
Ferroptosis is a non-apoptotic form of cell death caused by excessive iron exposure. The
role played by the ferroptosis-related genes and pathways in multiple myeloma (MM) is …

Novel targeted drugs for the treatment of multiple myeloma: from bench to bedside

B Bruno, L Giaccone, M Rotta, K Anderson… - Leukemia, 2005 - nature.com
Multiple myeloma remains an incurable plasma cell neoplasm. New insights into its
pathogenesis have identified signaling pathways that have become potential therapeutic …

P855: FERROPTOSIS AS A NEW BCMA-TARGETED IMMUNOTHERAPY OFF-TARGET EFFECT IN MULTIPLE MYELOMA

E La Spina, A Romano, D Tibullo, C Giallongo… - …, 2023 - journals.lww.com
Background: Triple-class or penta-drug refractory Multiple Myeloma (MM) patients develop
multi-drug-resistant disease with poor survival. BCMA is a transmembrane receptor …

[HTML][HTML] Current Novel Targeted Therapeutic Strategies in Multiple Myeloma

CHT Lin, MJ Tariq, F Ullah, A Sannareddy… - International Journal of …, 2024 - mdpi.com
Multiple myeloma (MM) is a hematologic malignancy caused by the clonal expansion of
immunoglobulin-producing plasma cells in the bone marrow and/or extramedullary sites …

[HTML][HTML] Breaking through multiple myeloma: a paradigm for a comprehensive tumor ecosystem targeting

AG Solimando, M Krebs, V Desantis, D Marziliano… - Biomedicines, 2023 - mdpi.com
Multiple myeloma (MM) is a cancerous condition characterized by the proliferation of plasma
cells within the hematopoietic marrow, resulting in multiple osteolytic lesions. MM patients …

Targeting intrinsic and extrinsic vulnerabilities for the treatment of multiple myeloma

N Anreddy, LA Hazlehurst - Journal of cellular biochemistry, 2017 - Wiley Online Library
Multiple myeloma (MM) is a malignant plasma cell disorder, clinically characterized by
osteolytic lesions, immunodeficiency, and renal disease. Over the past decade, MM therapy …

Identification and validation of novel therapeutic targets for multiple myeloma

T Hideshima, D Chauhan, P Richardson… - Journal of Clinical …, 2005 - ascopubs.org
In vitro and in vivo models have been developed that have allowed for delineation of
mechanisms of multiple myeloma (MM) cell homing to bone marrow (BM); tumor cell …