The relationship between heightened neuroinflammation and cognitive decline in the
normally aged brain is still debatable, as most data are derived from insult-related models …

Inflammatory cytokines and chemokines related to the innate and adaptive immune system
have been linked to neuroinflammation in Alzheimer's Disease, dementia, and cognitive …

Background Age-related cognitive dysfunction, including impairment of hippocampus-
dependent spatial learning and memory, affects approximately half of the aged population …

Cognitive impairment in learning, memory, and executive function occurs in normal aging
even in the absence of Alzheimer's disease (AD). While neurons do not degenerate in …

Chronic neuroinflammation, which is primarily mediated by microglia, plays an essential role
in aging and neurodegeneration. It is still unclear whether this microglia-induced …

Background Despite widespread acceptance that neuroinflammation contributes to age-
related cognitive decline, studies comparing protein expression of cytokines in the young …

Traumatic brain injury is increasingly common in older individuals. Older age is one of the
strongest predictors for poor prognosis after brain trauma, a phenomenon driven by the …

Aging is associated with increased glial responsiveness that may enhance the brain's
susceptibility to injury and disease. To determine whether unique age-related molecular …

Neuroinflammation is a risk factor for Alzheimer's disease (AD). We sought to study the glial
derangement in AD using diverse experimental models and human brain tissue. Besides …

In normal brain aging, CNS resident macrophages exhibit increased expression of major
histocompatibility complex (MHC) II expression. However, the transcriptional basis for this …