Guiding clinical malaria vaccine development using immune cell monitoring and controlled human malaria infection

J Ibanez Molina - 2023 - ub01.uni-tuebingen.de
Despite being treatable and preventable, malaria kills about half a million people each year,
mostly in Africa. Notwithstanding many attempts to develop a malaria vaccine, only the …

[HTML][HTML] Immune responses associated with protection induced by chemoattenuated PfSPZ vaccine in malaria-naive Europeans

YD Mouwenda, SP Jochems, V Van Unen… - JCI …, 2024 - Am Soc Clin Investig
Vaccination of malaria-naive volunteers with a high dose of Plasmodium falciparum
sporozoites chemoattenuated by chloroquine (CQ)(PfSPZ-CVac [CQ]) has previously …

Cellular immunity in Tanzanian volunteers upon malaria vaccination and controlled human malaria infection

T Rutishauser - 2018 - edoc.unibas.ch
Despite considerable efforts and achievements, malaria continues to be one of the most
devastating infectious diseases in the world. Clearly, an effective vaccine against malaria …

[HTML][HTML] Malaria vaccines since 2000: progress, priorities, products

PE Duffy, J Patrick Gorres - npj Vaccines, 2020 - nature.com
Malaria vaccine development entered a new era in 2015 when the pre-erythrocytic
Plasmodium falciparum candidate RTS, S was favorably reviewed by the European …

Malaria vaccines: past, present and future

L Von Seidlein, P Bejon - Archives of disease in childhood, 2013 - adc.bmj.com
The currently available malaria control tools have allowed malaria elimination in many
regions but there remain many regions where malaria control has made little progress. A …

Malaria vaccine approval: A step change for global health

A Gumulira - N. Engl. J. Med, 2021 - thelancet.com
On Oct 6, WHO announced that it will be recommending widespread use of the RTS, S/AS01
(RTS, S) malaria vaccine for children in sub-Saharan Africa and in other regions with …

[HTML][HTML] The Need for Novel Asexual Blood-Stage Malaria Vaccine Candidates for Plasmodium falciparum

E Takashima, H Otsuki, M Morita, D Ito, H Nagaoka… - Biomolecules, 2024 - mdpi.com
Extensive control efforts have significantly reduced malaria cases and deaths over the past
two decades, but in recent years, coupled with the COVID-19 pandemic, success has …

Current milestones towards development of a fully deployable anti-malaria vaccine-future hope for malaria-free world: a review

JK Karanja, NG Kiboi - 2016 - repository.seku.ac.ke
Despite novel global measures to combat malaria, the disease remains a considerable
healthcare burden especially in resource limited settings. It accounts for over 2 million …

[PDF][PDF] The RTS, S vaccine—a chance to regain the upper hand against malaria?

P Sinnis, DA Fidock - Cell, 2022 - cell.com
Malaria is estimated by the World Health Organization (WHO) to have killed 627,000
individuals worldwide in 2020, with nearly 80% of deaths in African children younger than …

[HTML][HTML] Advances in malaria vaccine development: report from the 2017 malaria vaccine symposium

CH Coelho, JYA Doritchamou, I Zaidi, PE Duffy - npj Vaccines, 2017 - nature.com
Abstract The Malaria Vaccine Symposium occurred at Johns Hopkins University in
Baltimore, MD, USA on April 25th, 2017, coinciding with World Malaria Day and the WHO …