Merkel cell polyomavirus small T antigen promotes pro-glycolytic metabolic perturbations required for transformation
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a
highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for …
highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for …
Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration
LM Knight, G Stakaityte, JJ Wood… - Journal of …, 2015 - Am Soc Microbiol
Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a
high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes …
high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes …
Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility
Merkel cell carcinoma (MCC) is an aggressive skin cancer with high rates of recurrence and
metastasis. Merkel cell polyomavirus (MCPyV) is associated with the majority of MCC cases …
metastasis. Merkel cell polyomavirus (MCPyV) is associated with the majority of MCC cases …
[PDF][PDF] Identifying the target cells and mechanisms of Merkel cell polyomavirus infection
Infection with Merkel cell polyomavirus (MCPyV) can lead to Merkel cell carcinoma (MCC), a
lethal form of skin cancer. However, the skin cell type productively infected by MCPyV …
lethal form of skin cancer. However, the skin cell type productively infected by MCPyV …
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
Merkel cell polyomavirus (MCV) is the recently discovered cause of most Merkel cell
carcinomas (MCCs), an aggressive form of nonmelanoma skin cancer. Although MCV is …
carcinomas (MCCs), an aggressive form of nonmelanoma skin cancer. Although MCV is …
Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential
JF Yang, W Liu, J You - PLoS Pathogens, 2023 - journals.plos.org
Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel
cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled …
cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled …
Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development
Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the
highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of …
highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of …
Merkel cell polyomavirus infection and detection
Merkel cell polyomavirus (MCPyV) infection can lead to Merkel cell carcinoma (MCC), a
highly aggressive form of skin cancer. Mechanistic studies to fully investigate MCPyV …
highly aggressive form of skin cancer. Mechanistic studies to fully investigate MCPyV …
Merkel cell polyomavirus infection and Merkel cell carcinoma
W Liu, M MacDonald, J You - Current opinion in virology, 2016 - Elsevier
Highlights•MCPyV infection is highly prevalent in the general population.•In elderly and
immunosuppressed individuals, MCPyV can cause Merkel cell carcinoma.•LT and sT …
immunosuppressed individuals, MCPyV can cause Merkel cell carcinoma.•LT and sT …
Molecular mechanisms of merkel cell polyomavirus transformation and replication
W Liu, J You - Annual review of virology, 2020 - annualreviews.org
Viral infection underlies a significant share of the global cancer burden. Merkel cell
polyomavirus (MCPyV) is the newest member of the human oncogenic virus family. Its …
polyomavirus (MCPyV) is the newest member of the human oncogenic virus family. Its …