Merkel cell polyomavirus small T antigen promotes pro-glycolytic metabolic perturbations required for transformation

C Berrios, M Padi, MA Keibler, DE Park, V Molla… - PLoS …, 2016 - journals.plos.org
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a
highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for …

Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration

LM Knight, G Stakaityte, JJ Wood… - Journal of …, 2015 - Am Soc Microbiol
Merkel cell carcinoma (MCC) is an aggressive skin cancer of neuroendocrine origin with a
high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) causes …

Merkel cell polyomavirus small tumour antigen activates the p38 MAPK pathway to enhance cellular motility

SJ Dobson, A Anene, JR Boyne, J Mankouri… - Biochemical …, 2020 - portlandpress.com
Merkel cell carcinoma (MCC) is an aggressive skin cancer with high rates of recurrence and
metastasis. Merkel cell polyomavirus (MCPyV) is associated with the majority of MCC cases …

[PDF][PDF] Identifying the target cells and mechanisms of Merkel cell polyomavirus infection

W Liu, R Yang, AS Payne, RM Schowalter… - Cell host & …, 2016 - cell.com
Infection with Merkel cell polyomavirus (MCPyV) can lead to Merkel cell carcinoma (MCC), a
lethal form of skin cancer. However, the skin cell type productively infected by MCPyV …

Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator

M Shuda, HJ Kwun, H Feng, Y Chang… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Merkel cell polyomavirus (MCV) is the recently discovered cause of most Merkel cell
carcinomas (MCCs), an aggressive form of nonmelanoma skin cancer. Although MCV is …

Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential

JF Yang, W Liu, J You - PLoS Pathogens, 2023 - journals.plos.org
Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel
cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled …

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development

ME Spurgeon, J Cheng, E Ward-Shaw, FA Dick… - PLoS …, 2022 - journals.plos.org
Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the
highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of …

Merkel cell polyomavirus infection and detection

W Liu, NA Krump, CB Buck, J You - JoVE (Journal of Visualized …, 2019 - jove.com
Merkel cell polyomavirus (MCPyV) infection can lead to Merkel cell carcinoma (MCC), a
highly aggressive form of skin cancer. Mechanistic studies to fully investigate MCPyV …

Merkel cell polyomavirus infection and Merkel cell carcinoma

W Liu, M MacDonald, J You - Current opinion in virology, 2016 - Elsevier
Highlights•MCPyV infection is highly prevalent in the general population.•In elderly and
immunosuppressed individuals, MCPyV can cause Merkel cell carcinoma.•LT and sT …

Molecular mechanisms of merkel cell polyomavirus transformation and replication

W Liu, J You - Annual review of virology, 2020 - annualreviews.org
Viral infection underlies a significant share of the global cancer burden. Merkel cell
polyomavirus (MCPyV) is the newest member of the human oncogenic virus family. Its …