Pseudomonas aeruginosa maintains an inducible array of novel and diverse prophages over lengthy persistence in CF lungs

I Kyrkou, J Bartell, A Lechuga, C Lood, RL Marvig… - 2024 - researchsquare.com
Pseudomonas aeruginosa is a bacterium with increasing relevance in clinical settings and
among the most common bacteria occupying the cystic fibrosis (CF) lung niche. Its ability to …

Temperate bacteriophages from chronic Pseudomonas aeruginosa lung infections show disease-specific changes in host range and modulate antimicrobial …

MA Tariq, FLC Everest, LA Cowley, R Wright, GS Holt… - …, 2019 - Am Soc Microbiol
Temperate bacteriophages are a common feature of Pseudomonas aeruginosa genomes,
but their role in chronic lung infections is poorly understood. This study was designed to …

The effect of a bacteriophage on diversification of the opportunistic bacterial pathogen, Pseudomonas aeruginosa

MA Brockhurst, A Buckling… - Proceedings of the …, 2005 - royalsocietypublishing.org
Pseudomonas aeruginosa is an opportunistic human pathogen that colonizes the lungs of
cystic fibrosis (CF) patients. CF lungs often contain a diverse range of P. aeruginosa …

Diversity of Pseudomonas aeruginosa temperate phages

G Johnson, S Banerjee, C Putonti - Msphere, 2022 - Am Soc Microbiol
Modern sequencing technologies have provided insight into the genetic diversity of
numerous species, including the human pathogen Pseudomonas aeruginosa. Bacterial …

The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung

S O'Brien, JL Fothergill - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a major pathogen in the lungs of cystic fibrosis (CF) patients.
However, it is now recognised that a diverse microbial community exists in the airways …

Comparative genomics and biological characterization of sequential Pseudomonas aeruginosa isolates from persistent airways infection

I Bianconi, J Jeukens, L Freschi, B Alcalá-Franco… - BMC genomics, 2015 - Springer
Background Pseudomonas aeruginosa establishes life-long chronic airway infections in
cystic fibrosis (CF) patients. As the disease progresses, P. aeruginosa pathoadaptive …

Universal soldier: Pseudomonas aeruginosa — an opportunistic generalist

J Gross, IJ Passmore, JCS Chung, O Rzhepishevska… - Frontiers in biology, 2013 - Springer
The opportunistic pathogen Pseudomonas aeruginosa commonly causes chronic and
ultimately deadly lung infections in individuals with the genetic disease cystic fibrosis (CF) …

Co-occurring microflora and mucin drive Pseudomonas aeruginosa diversification and pathoadaptation

MJ Bottery, HK Johansen, JW Pitchford… - ISME …, 2024 - academic.oup.com
While several environmental factors contribute to the evolutionary diversification of the
pathogenic bacterium Pseudomonas aeruginosa during cystic fibrosis lung infections …

[图书][B] The diverse impact of bacteriophages on the bacterial host

JW Bondy-Denomy - 2014 - search.proquest.com
The viruses that infect bacteria, bacteriophages (or phages) are the most abundant
biological entities on the planet. Phages are constantly causing bacterial population …

Evolution of bacterial “frenemies”

SE Darch, CB Ibberson, M Whiteley - MBio, 2017 - Am Soc Microbiol
Chronic polymicrobial infections are associated with increased virulence compared to
monospecies infections. However, our understanding of microbial dynamics during …