Cryoablation: a promising non-operative therapy for low-risk breast cancer

Z Habrawi, MW Melkus, S Khan, J Henderson… - The American Journal of …, 2021 - Elsevier
Background The aim of this study was to evaluate the feasibility of cryoablation for early-
stage low-risk breast cancer without tumor resection. Methods Women diagnosed with ER+ …

Cryoablation therapy for early-stage breast cancer: evidence and rationale

JN Thai, AB Sevrukov, RC Ward… - Journal of Breast …, 2023 - academic.oup.com
Recent advances in breast cancer research and treatment propel a paradigm shift toward
less aggressive and less invasive treatment for some early-stage breast cancer. Select …

Cryoablation of early-stage breast cancer: work-in-progress report of a multi-institutional trial

MS Sabel, CS Kaufman, P Whitworth, H Chang… - Annals of surgical …, 2004 - Springer
Background With recent improvements in breast imaging, our ability to identify small breast
tumors has markedly improved, prompting significant interest in the use of ablation without …

Cryoablation Without Excision for Early-Stage Breast Cancer: ICE3 Trial 5-Year Follow-Up on Ipsilateral Breast Tumor Recurrence

RE Fine, RC Gilmore, KR Tomkovich, JR Dietz… - Annals of Surgical …, 2024 - Springer
Background The ICE3 trial evaluated the safety and efficacy of cryoablation in women
aged≥ 60 years with low-risk, early-stage breast cancers, aiming to provide a non-operative …

The role of cryoablation in breast cancer beyond the oncologic control: COST and breast-Q patient-reported outcomes

SY Khan, A Snitman, Z Habrawi, S Crawford… - Annals of Surgical …, 2023 - Springer
Background Cryoablation has been established as a minimally invasive alternative to
resection of early-stage breast cancer; however, there are no data on the cost and impact on …

Cryoablation of Primary Breast Cancer in Patients Ineligible for Clinical Trials: A Multiinstitutional Study

K Oueidat, GL Baird, B Barclay-White… - American Journal of …, 2024 - ajronline.org
Background: Breast cancer cryoablation clinical trials have strict inclusion criteria that
exclude patients with potentially treatable disease. Objective: This study's purpose was to …

Cryoablation without excision for low-risk early-stage breast cancer: 3-year interim analysis of ipsilateral breast tumor recurrence in the ICE3 trial

RE Fine, RC Gilmore, JR Dietz, SK Boolbol… - Annals of surgical …, 2021 - Springer
Background The ICE3 trial is designed to evaluate the safety and efficacy of breast
cryoablation, enabling women older than 60 years with low-risk early-stage breast cancers …

A phase II trial exploring the success of cryoablation therapy in the treatment of invasive breast carcinoma: results from ACOSOG (Alliance) Z1072

RM Simmons, KV Ballman, C Cox, N Carp… - Annals of surgical …, 2016 - Springer
Background Cryoablation is a well-established technique to treat fibroadenomas. Pilot
studies suggest this could be an effective non-surgical treatment for breast cancer. American …

Cryoablation allows the ultimate de-escalation of surgical therapy for select breast cancer patients

SY Khan, J Cole, Z Habrawi, MW Melkus… - Annals of Surgical …, 2023 - Springer
Background Widespread use of screening mammography has allowed breast cancer to be
detected at earlier stages. This allows for increased customization of treatment and less …

Breast cancer cryoablation fundamentals past and present: technique optimization and imaging pearls

ML Huang, K Tomkovich, DL Lane, R Katta… - Academic radiology, 2023 - Elsevier
Surgical treatment for breast cancer has evolved from radical mastectomy to modified radical
mastectomy to breast-conserving surgery. As the de-escalation of surgical treatment for …