Exposure to adversity is associated with psychiatric disorders, and delineating the
mechanisms underlying the association is critical for optimizing risk identification and …

Various psychological and biological pathways have been proposed as mediators between
childhood adversity (CA) and psychosis. A systematic review of the evidence in this domain …

Child abuse is associated with markedly elevated rates of major depression and other
psychiatric disorders in adulthood. This article reviews preclinical studies examining the …

The neurobiological mechanisms by which childhood maltreatment heightens vulnerability
to psychopathology remain poorly understood. It is likely that a complex interaction between …

Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …

Early life adversity (ELA)-which includes physical, psychological, emotional, and sexual
abuse is one of the most common predictors to diverse psychopathologies later in …

A review of the human developmental neuroimaging literature that investigates outcomes
following exposure to psychosocial adversity is presented with a focus on two subcortical …

Two extant frameworks–the harshness-unpredictability model and the threat-deprivation
model–attempt to explain which dimensions of adversity have distinct influences on …

Adversity exposure is a risk factor for psychopathology, which most frequently onsets during
adolescence, and prior research has demonstrated that alterations in cortico-limbic …

Current frameworks for understanding the link between early adverse childhood
experiences and later negative life outcomes, including psychopathology, focus on the …