The initiation and progression of breast cancer (BRCA) is associated with inflammation and
immune-overactivation, which is critically modulated by the E3 ubiquitin ligase. However, the …

Triple-negative breast cancers (TNBCs) are characterized by high rates of recurrence and
poor clinical outcomes. Deregulated E3 ligases are involved in breast cancer pathogenesis …

Background FBXL8 is a conserved F‐box protein, belonging to the ubiquitin ligase complex,
which promotes the development and progression of tumours. However, the regulation …

F-box and leucine-rich repeat protein 7 (FBXL7), an F-box protein responsible for substrate
recognition by the SKP1-Cullin-1-F-box (SCF) ubiquitin ligases, plays an emerging role in …

Simple Summary The dysregulation of UPS exacerbates the tumor microenvironment and
drives malignant transformation. As the largest family of E3 ligases, the SCFF-boxes …

The F-box protein 22 (FBXO22), an F-box E3 ligase, has been identified to be critically
involved in carcinogenesis. However, a systematic assessment of the role of FBXO22 across …

Simple Summary Fbxo4 is an E3 ubiquitin ligase that requires the formation of a complex
with S-phase kinase-associated protein 1 and Cullin1 to catalyze the ubiquitylation of its …

Epigenetic plasticity is a pivotal factor that drives metastasis. Here, we show that the
promoter of the gene that encodes the ubiquitin ligase subunit FBXL7 is hypermethylated in …

The F-box and WD-repeat-containing protein 2 (FBXW2) plays a crucial role as an E3 ligase
in regulating tumorigenesis. However, the functions of FBXW2 in breast cancer are still …

Introduction: F-box proteins are the substrate-recognizing subunits of SKP1 (S-phase kinase-
associated protein 1)–cullin1–F-box protein (SCF) E3 ligase complexes that play pivotal …