The tip complex: From host cell sensing to translocon formation
WD Picking, ML Barta - Bacterial type III protein secretion systems, 2020 - Springer
Type III secretion systems are used by some Gram-negative bacteria to inject effector
proteins into targeted eukaryotic cells for the benefit of the bacterium. The type III secretion …
proteins into targeted eukaryotic cells for the benefit of the bacterium. The type III secretion …
The injectisome, a complex nanomachine for protein injection into mammalian cells
M Lara-Tejero, JE Galán - EcoSal Plus, 2019 - Am Soc Microbiol
Type III protein secretion systems (T3SSs), or injectisomes, are multiprotein nanomachines
present in many Gram-negative bacteria that have a sustained long-standing close …
present in many Gram-negative bacteria that have a sustained long-standing close …
Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …
The type III secretion injectisome
GR Cornelis - Nature Reviews Microbiology, 2006 - nature.com
The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …
Type 3 secretion systems
LJ Worrall, JRC Bergeron, NCJ Strynadka - Escherichia coli, 2013 - Elsevier
The bacterial type III secretion system is used by pathogenic Gram-negative bacteria to
transfer toxin proteins directly into the cytoplasm of eukaryotic hosts. Pathogenic E. coli …
transfer toxin proteins directly into the cytoplasm of eukaryotic hosts. Pathogenic E. coli …
Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes
Bacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …
Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome
Type III secretion systems are multiprotein molecular machines required for the virulence of
several important bacterial pathogens. The central element of these machines is the …
several important bacterial pathogens. The central element of these machines is the …
The type III secretion system sorting platform
M Lara-Tejero - Bacterial Type III Protein Secretion Systems, 2020 - Springer
A central feature of type III protein secretion machines is their ability to engage their
substrates in a hierarchical and organized fashion. The hierarchy in the secretion process is …
substrates in a hierarchical and organized fashion. The hierarchy in the secretion process is …
Structure of a pathogenic type 3 secretion system in action
J Radics, L Königsmaier, TC Marlovits - Nature structural & molecular …, 2014 - nature.com
Abstract Type 3 secretion systems use 3.5-megadalton syringe-like, membrane-embedded'
injectisomes', each containing an~ 800-Å-long needle complex to connect intracellular …
injectisomes', each containing an~ 800-Å-long needle complex to connect intracellular …
The type III secretion system tip complex and translocon
CA Mueller, P Broz, GR Cornelis - Molecular microbiology, 2008 - Wiley Online Library
The type III secretion machinery of Gram‐negative bacteria, also known as the injectisome
or needle complex, is composed of a basal body spanning both bacterial membranes and …
or needle complex, is composed of a basal body spanning both bacterial membranes and …