The tip complex: From host cell sensing to translocon formation

WD Picking, ML Barta - Bacterial type III protein secretion systems, 2020 - Springer
Type III secretion systems are used by some Gram-negative bacteria to inject effector
proteins into targeted eukaryotic cells for the benefit of the bacterium. The type III secretion …

The injectisome, a complex nanomachine for protein injection into mammalian cells

M Lara-Tejero, JE Galán - EcoSal Plus, 2019 - Am Soc Microbiol
Type III protein secretion systems (T3SSs), or injectisomes, are multiprotein nanomachines
present in many Gram-negative bacteria that have a sustained long-standing close …

Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells

S Wagner, I Grin, S Malmsheimer… - FEMS microbiology …, 2018 - academic.oup.com
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial
effector proteins into eukaryotic host cells. They are able to secrete a great diversity of …

The type III secretion injectisome

GR Cornelis - Nature Reviews Microbiology, 2006 - nature.com
The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …

Type 3 secretion systems

LJ Worrall, JRC Bergeron, NCJ Strynadka - Escherichia coli, 2013 - Elsevier
The bacterial type III secretion system is used by pathogenic Gram-negative bacteria to
transfer toxin proteins directly into the cytoplasm of eukaryotic hosts. Pathogenic E. coli …

Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes

A Meir, K Macé, Y Vegunta, SM Williams… - Trends in …, 2023 - cell.com
Bacteria use a wide arsenal of macromolecular substrates (DNA and proteins) to interact
with or infect prokaryotic and eukaryotic cells. To do so, they utilize substrate-injecting …

Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome

EZ Guo, JE Galán - … of the National Academy of Sciences, 2021 - National Acad Sciences
Type III secretion systems are multiprotein molecular machines required for the virulence of
several important bacterial pathogens. The central element of these machines is the …

The type III secretion system sorting platform

M Lara-Tejero - Bacterial Type III Protein Secretion Systems, 2020 - Springer
A central feature of type III protein secretion machines is their ability to engage their
substrates in a hierarchical and organized fashion. The hierarchy in the secretion process is …

Structure of a pathogenic type 3 secretion system in action

J Radics, L Königsmaier, TC Marlovits - Nature structural & molecular …, 2014 - nature.com
Abstract Type 3 secretion systems use 3.5-megadalton syringe-like, membrane-embedded'
injectisomes', each containing an~ 800-Å-long needle complex to connect intracellular …

The type III secretion system tip complex and translocon

CA Mueller, P Broz, GR Cornelis - Molecular microbiology, 2008 - Wiley Online Library
The type III secretion machinery of Gram‐negative bacteria, also known as the injectisome
or needle complex, is composed of a basal body spanning both bacterial membranes and …