Kontogiannis et al. Mitochondria in β-adrenergic signaling mitochondria (7). Metoprolol was
later shown to inhibit β oxidation by downregulating carnitine palmitoyl-transferase I (8) …

Abstract Purpose of Review We review therapeutic approaches aimed at restoring function
of the failing heart by targeting mitochondrial reactive oxygen species (ROS), ion handling …

Arrhythmia and cardiac hypertrophy are two very common cardiovascular diseases that can
lead to heart failure and even sudden death, thus presenting a serious threat to human life …

Mitochondria have a central role in normal cardiac muscle function. To sustain electrical and
mechanical activities, the heart on average needs to synthesis anywhere from 6 kg to 30kg …

Background: Mitochondria are cellular organelles responsible for energy production,
calcium handling, controlled synthesis of reactive oxygen species (ROS), and regulation of …

The current therapy for patients with stable systolic heart failure is largely limited to
treatments that interfere with neurohormonal activation. Critical pathophysiological …

This editorial refers to the following articles in this issue which are part of the Review Focus
on Mitochondria in Cardiac Disease: Emerging Concepts and Novel Therapeutic Targets: T …

Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

Mitochondrial dysfunction is considered as a crucial contributory factor in cardiac pathology.
This has highlighted the therapeutic potential of targeting mitochondria to prevent or treat …

Mitochondrial dysfunction is a hallmark of common cardiovascular disorders, including
ischemia–reperfusion injury, hypertrophy, heart failure, and diabetes mellitus. While the role …