Intramyocellular lipid content (IMCL) serves as a good biomarker of skeletal muscle insulin
resistance (IR). However, intracellular fatty acid metabolites [malonyl-CoA, long-chain acyl …

Chronic high-fat feeding in rats induces profound whole-body insulin resistance, mainly due
to effects in oxidative skeletal muscle. The mechanisms of this reaction remain unclear, but …

The physiological dynamics of intramyocellular lipids (IMCLs) in different muscle types and
of hepatocellular lipids (HepCLs) are still uncertain. The dynamics of IMCLs in the soleus …

Insulin has been shown to alter long-chain fatty acid (LCFA) metabolism and malonyl-CoA
production in muscle. However, these alterations may have been induced, in part, by the …

The present article addresses the hypothesis that disturbances in skeletal muscle fatty acid
handling in abdominal obesity and type 2 diabetes mellitus may play a role in the aetiology …

Altered muscle fatty acid (FA) metabolism may contribute to the presence of muscle insulin
resistance in the genetically obese Zucker rat. To determine whether FA uptake and …

The effect of muscle fiber type and maturation on intramyocellular lipid (IMCL) content and
its relationship to insulin resistance was investigated. Intramyocellular lipid content in slow …

Insulin resistance (IR) is the result of long-lasting positive energy balance and the imbalance
between the uptake of energy rich substrates (glucose, lipids) and energy output. The …

Elevated plasma free fatty acids (FFA) cause insulin resistance and are thought to play a key
role in mediating insulin resistance in patients with the metabolic syndrome (MTS) and type …

There is a debate on whether lipid-mediated insulin resistance derives from an increased or
decreased capacity of muscle to oxidize fats. Here, we examine the involvement of muscle …