High levels of some but not all dietary fats lead to insulin resistance in rats. The aim of this
study was to investigate the important determinants underlying this observation. Insulin …

Intramuscular accumulation of bioactive lipids leads to insulin resistance and type 2
diabetes (T2D). There is lack of consensus concerning which of the lipid mediators has the …

The effect of muscle fiber type and maturation on intramyocellular lipid (IMCL) content and
its relationship to insulin resistance was investigated. Intramyocellular lipid content in slow …

In humans and animal models, increased lipid content of skeletal muscle is strongly
associated with insulin resistance. However, it is unclear whether this accumulation is due to …

A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has been
proposed as a major factor leading to the accumulation of intramuscular lipids and their …

High visceral adiposity and intramyocellular lipid levels (IMCL) are both associated with the
development of type 2 diabetes. The relationship between visceral adiposity and IMCL …

Increases in intramyocellular long-chain fatty acyl-CoAs (LCACoA) have been implicated in
the pathogenesis of insulin resistance in skeletal muscle. To test this hypothesis, we …

The etiology of insulin resistance in Type 1 Diabetes (T1D) is unknown, however it affects
approximately 20% of T1D patients. Intramyocellular lipids (IMCL) have been identified as a …

Increased plasma levels of free fatty acids (FFA) occur in states of insulin resistance such as
obesity and type 2 diabetes mellitus. These high levels of plasma FFA are proposed to play …

The present article addresses the hypothesis that inefficient skeletal muscle lipid utilization
may relate to the development of obesity and insulin resistance. In practice, there is …