Aims/hypothesis Although insulin resistance has been associated with accumulations of
specific intramuscular fatty acids and altered subcellular localisation of lipid droplets, these …

Insulin-mediated muscle glycogen synthesis is impaired after several weeks of high-fat
feeding in rats, but not by short-term (2-hour) nonesterified fatty acids (NEFA) elevation …

Glucose infusion in rats for 1–4 days results in insulin resistance and increased triglyceride,
whole tissue long-chain fatty acyl-CoA (LCA-CoA), and malonyl-CoA content in red skeletal …

Non-insulin-dependent diabetes (NIDDM) is characterized by overproduction of glucose,
decreased effects of insulin on glucose utilization and production, and a defect in glucose …

Insulin resistance in skeletal muscle is associated with 1) relative increases in the proportion
of glycolytic and fast-twitch muscle fibers and decreases in the proportion of more oxidative …

The intracellular triglyceride content in skeletal muscle is increased in insulin-resistant states
such as obesity or high-fat feeding. It has been hypothesized that increased fatty acid …

To elucidate cellular mechanisms of insulin resistance induced by excess dietary fat, we
studied conscious chronically high-fat–fed (HFF) and control chow diet-fed rats during …

Patients with insulin resistance and type 2 diabetes (T2DM) commonly exhibit elevated
plasma free fat acid (FFA) and muscle fat (triglyceride) levels, which may either represent …

Skeletal muscle insulin resistance is a co-morbidity of obesity and a risk factor for the
development of type 2 diabetes mellitus. Insulin resistance is associated with the …

To examine whether and how intramyocellular lipid (IMCL) content contributes to
interindividual variation in insulin action, we studied 20 healthy men with no family history of …