The accumulation of intramyocellular lipid (IMCL) is recognized as an important determinant
of insulin resistance, and is increased by a high-fat diet (HFD). However, the effects of HFD …

A close relationship between elevated plasma free fatty acid (FFA) levels and insulin
resistance is commonly reported in obese subjects. The aim of the present study was to …

Currently inherited or acquired skeletal muscle mitochondrial dysfunction is linked to
dysregulated fatty acid metabolism, resulting in increased levels of intramyocellular lipids …

Consumption of a Western diet rich in saturated fats is associated with obesity and insulin
resistance. In some insulin-resistant phenotypes this is associated with accumulation of …

We examined the effect of insulin on the synthesis and degradation of muscle lipid pools
[phospholipid (PL), diacylglycerol (DG), triacylglycerol (TG)] and palmitate oxidation in …

Context: Increased adipose tissue lipolytic activity is considered an important factor in the
pathogenesis of skeletal muscle insulin resistance associated with obesity. Objective: The …

Aims/hypothesis The mechanisms for diet-induced intramyocellular lipid accumulation and
its association with insulin resistance remain contentious. In a detailed time-course study in …

Introduction/hypothesis Disturbances in skeletal muscle fatty acid (FA) handling may
contribute to the development and progression of whole-body insulin resistance (IR). In this …

Lipid oversupply plays a role in developing insulin resistance in skeletal muscle, decreasing
expression of nuclear-encoded mitochondrial genes, and increasing extracellular matrix …

ABSTRACT A number of biochemical defects have been identified in glucose metabolism
within skeletal muscle in obesity, and positive effects of weight loss on insulin resistance are …