Platelet activation, thrombus growth and subsequent thromboembolism underpins the
pathophysiology of ischaemic stroke. At sites of atherothrombotic plaque rupture, it is …

Background Platelets are essential to physiological hemostasis or pathological thrombus
formation. Current antiplatelet agents inhibit platelet aggregation but leave patients at risk of …

Objectives Platelet activation underpins thrombus formation in ischemic stroke. The active,
dimeric form of platelet receptor glycoprotein (GP) VI plays key roles by binding platelet …

Platelet glycoprotein VI (GPVI) is the principal signalling receptor for collagen, which is
exposed upon damage to the extracellular matrix and at site of rupture of an atherosclerotic …

Background and purpose: Platelet collagen receptor glycoprotein VI (GPVI) contributes
significantly to platelet adhesion and thrombus formation. We aimed to investigate GPVI in …

Platelets play a central role in arrest of bleeding. The ability of platelets to engage with
extracellular matrix proteins of the subendothelium has long been recognised as a pivotal …

Platelet glycoprotein (GP) VI is a promising, safe, antithrombotic target as its absence or
blockade prevents in vitro thrombus formation and experimental thrombosis in various …

Platelet glycoprotein VI (GPVI) acts as a decisive collagen receptor in atherothrombosis.
Besides collagen, injured atherosclerotic plaques expose tissue factor (TF) that triggers …

Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury
and supports the recruitment of circulating platelets. In addition to integrin αIIbβ3, another as …

Platelets respond immediately to vascular injury by adhesion, aggregation, and thrombus
formation. Disruption of the endothelial cell layer exposes extracellular matrix to the …