Platelets respond immediately to vascular injury by adhesion, aggregation, and thrombus
formation. Disruption of the endothelial cell layer exposes extracellular matrix to the …

Glycoprotein (GP) VI is a transmembrane receptor of~ 65 kDa only expressed on the
megakaryocyte-platelet lineage [1]. GPVI, the central platelet collagen receptor that also …

Lipid‐rich atherosclerotic plaques are vulnerable, and their rupture can cause the formation
of a platelet‐and fibrin‐rich thrombus leading to myocardial infarction and ischemic stroke …

Objective: Atherothrombosis occurs upon rupture of an atherosclerotic plaque and leads to
the formation of a mural thrombus. Computational fluid dynamics and numerical models …

Glycoprotein VI (GPVI) mediates collagen-induced platelet activation after vascular damage
and is an important contributor to the onset of thrombosis, heart attack, and stroke. Animal …

Coronary artery thrombosis and ischemic stroke are often initiated by the disruption of an
atherosclerotic plaque and consequent intravascular platelet activation. Thus, antiplatelet …

One of the key receptors involved in the prothrombotic stage of an acute coronary syndrome
(ACS) is platelet glycoprotein VI (GPVI). This constitutively expressed collagen receptor is …

Essentials• Glycoprotein VI (GPVI) binds collagen, starting thrombogenesis, and fibrin,
stabilizing thrombi.• GPVI‐dimers, not monomers, recognize immobilized fibrinogen and …

Injuries to the vessel wall and subsequent exposure of collagen from the subendothelial
matrix result in thrombus formation. In physiological conditions, the platelet plug limits blood …