Background and Purpose—Ischemic stroke induced by thrombosis may be triggered by
atherosclerotic plaque rupture and collagen-induced platelet activation. Collagen induces …

Platelet hyperreactivity is a major risk factor for thromboischaemic events such as
myocardial infarction and stroke. 1 Antiplatelet therapy has substantially improved morbidity …

Glycoprotein VI (GPVI) is a platelet surface receptor for collagen exposed to the blood
following platelet adhesion via GPIb-IX-V complex-vWF interaction on damage to the …

Glycoprotein VI (GPVI) is a membrane glycoprotein unique to platelets and has been
identified as a physiological receptor for collagen. Damage to a vessel wall exposes the …

Glycoprotein VI (GPVI) is an activating receptor expressed on the surface of platelets and
megakaryocytes. Clustering of GPVI upon collagen binding triggers a signaling cascade that …

GPVI (glycoprotein VI) is a platelet surface receptor whose best-known role is to provide an
activation signal when platelets adhere to injury-exposed collagen fibrils via GPIb …

Platelet interactions with adhesive ligands exposed at sites of vascular injury initiate the
normal hemostatic response but may also lead to arterial thrombosis. Platelet membrane …

Platelet—collagen interactions play a fundamental role in the process of arterial thrombosis.
The major platelet collagen receptor is the glycoprotein VI (GPVI). Here, we determined the …

Coronary artery thrombosis is often initiated by platelet activation on collagen-rich
subendothelial layers in the disrupted atherosclerotic plaque. The activating platelet …

Subendothelial collagen exposed to platelets after rupture of atherosclerotic plaques is the
main trigger of platelet activation und acute arterial thrombotic occlusion leading to …