New methods for analysing both platelet and plasma forms of the platelet-specific collagen
receptor, glycoprotein VI (GPVI) in experimental models or human clinical samples, and the …

Platelet activation is a key step in the pathogenesis of ischemic cardio-and cerebrovascular
diseases, which represent the leading causes of death and severe disability worldwide …

Essentials• Dimeric high‐affinity collagen receptor glycoprotein VI (GPVI) is present on
resting platelets.• Spatio‐temporal organization of platelet GPVI‐dimers was evaluated …

Cardiovascular disease is the leading cause of death globally and platelets have emerged
as key markers for disease pathophysiology. Cardiovascular disorders caused by …

Glycoprotein VI (GPVI), a membrane glycoprotein solely expressed in platelets and
megakaryocytes, plays a critical role in thrombus formation due to collagen/GPVI-mediated …

Lipid-rich atherosclerotic plaques are vulnerable, and upon disruption trigger intraarterial
thrombus formation. Tissue factor activating blood coagulation is viewed as the major …

Glycoprotein (GP) VI is a platelet membrane protein with a molecular weight of 62 kDa that
was identified as a physiological collagen receptor from studies of patients deficient in this …

Glycoprotein VI (GPVI), a platelet collagen receptor, is crucial in mediating
atherothrombosis. Besides collagen, injured plaques expose tissue factor (TF) that triggers …

Essentials• Platelets can stop bleeding independently of integrin‐mediated aggregation in
inflamed organs.• GPVI contributes to aggregation‐independent hemostasis in the inflamed …

Activation of circulating platelets by exposed vessel wall collagen is a primary step in the
pathogenesis of heart attack and stroke, and drugs to block platelet activation have …