Tetrahydronaphthalenic analogues of melatonin have been synthesized and evaluated as
melatonin receptor ligands. Introduction of a phenyl substituent in the 3-position of the …

A series of naphthalenic analogues of melatonin were prepared and evaluated as melatonin
receptor MT2 selective ligands. Activity and MT2 selectivity can be modulated with suitable …

Following our studies of the melatoninergic receptors, we have developed new
tetrahydronaphthalenic derivatives of melatonin that have been tested as selective …

Novel heterodimer analogues of melatonin were synthesized, when agomelatine (1) and
various aryl units are linked via a linear alkyl chain through the methoxy group. The …

Naphthalenic analogs of MCA-NAT (5-methoxycarbonylamino-N-acetyltryptamine) have
been synthesized and evaluated as melatonin receptor ligands. Introduction of a …

A series of chiral heterocyclic aminopyrrolidine derivatives was synthesized as novel
melatoninergic ligands. Binding affinity assays were performed on cloned human MT1 and …

A series of substituted N-[3-(3-methoxyphenyl) propyl] amides were synthesized and their
binding affinities towards human melatonin MT1 and MT2 receptors were evaluated. It was …

This work reports the design and synthesis of novel alkylamides, characterized by a dibenzo
[a, d] cycloheptene nucleus, as melatonin (MLT) receptor ligands. The tricyclic scaffold was …

Herein we report attempts to optimize the pharmacological properties of 5‐(2‐
hydroxyethoxy)‐N‐acetyltryptamine (5‐HEAT), a melatonin receptor ligand previously …

A novel series of 2-[(2, 3-dihydro-1 H-indol-1-yl) methyl] melatonin analogues has been
prepared to probe the steric and electronic properties of the binding pocket of the MT2 …