Effects of metabolites and analogs of amiodarone on alveolar macrophages: structure-activity relationship
D Quaglino, HR Ha, E Duner… - … of Physiology-Lung …, 2004 - journals.physiology.org
Amiodarone, an antiarrhythmic drug toxic toward the lung, is metabolized through sequential
modifications of the diethylaminoethoxy group to mono-N-desethylamiodarone (MDEA), di-N …
modifications of the diethylaminoethoxy group to mono-N-desethylamiodarone (MDEA), di-N …
Amiodarone pulmonary toxicity: morphologic and biochemical features
MJ Reasor, S Kacew - Proceedings of the Society for …, 1991 - journals.sagepub.com
Conclusions Since the discovery of amiodarone over 30 years ago, the mechanisms
underlying serious adverse effects remain to be resolved and still limit drug usefulness …
underlying serious adverse effects remain to be resolved and still limit drug usefulness …
Accumulation of amiodarone and desethylamiodarone by rat alveolar macrophages in cell culture
JM Antonini, MJ Reasor - Biochemical pharmacology, 1991 - Elsevier
Amiodarone is a clinically effective antiarrhythmic drug shown to cause lung damage in
humans and animals. While the mechanism of this pulmonary toxicity is unknown, it may be …
humans and animals. While the mechanism of this pulmonary toxicity is unknown, it may be …
Response of alveolar macrophages to amiodarone and desethylamiodarone, in vitro
CL Ogle, MJ Reasor - Toxicology, 1990 - Elsevier
Administration of the antiarrhythmic drug amiodarone to humans or animals may result in
lung damage. Amiodarone is metabolized to desethylamiodarone and other minor …
lung damage. Amiodarone is metabolized to desethylamiodarone and other minor …
Pulmonary accumulation of amiodarone and N-desethylamiodarone
BD Wilson, ML Lippmann - Am Rev Respir Dis, 1990 - atsjournals.org
Toinvestigate the relationship between the amount of amiodarone and the major metabolite
N-desethylamiodarone found in the lung with the development of toxicity, Fischer 344 and …
N-desethylamiodarone found in the lung with the development of toxicity, Fischer 344 and …
[HTML][HTML] Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro
R Bargout, A Jankov, E Dincer… - … of Physiology-Lung …, 2000 - journals.physiology.org
The antiarrhythmic amiodarone (AM) and its metabolite desethylamiodarone (Des) are
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …
known to cause AM-induced pulmonary toxicity, but the mechanisms underlying this …
Pulmonary responses to amiodarone in hamsters: Comparison of intratracheal and oral administrations
TL Blake, MJ Reasor - Toxicology and applied pharmacology, 1995 - Elsevier
Amiodarone (AD) has been shown to produce a transient pulmonary fibrosis in hamsters
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …
Amiodarone-induced pulmonary inflammation
BD Wilson, CE Clarkson, ML Lippmann - Am Rev Respir Dis, 1991 - atsjournals.org
Toinvestigate the hypotheses that amiodarone-induced pulmonary inflammation may be
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …
related to direct drug toxicity, groups of 10or more Wistar rats were fed amiodarone by …
Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells
JE Mulder, JF Brien, WJ Racz, T Takahashi… - … of Pharmacology and …, 2011 - ASPET
Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-
threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may …
threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM metabolite, may …
Synthesis and cytotoxicity properties of amiodarone analogues
Amiodarone (AMI) is a potent antiarrhythmic agent; however, its clinical use is limited due to
numerous side effects. In order to investigate the structure–cytotoxicity relationship, AMI …
numerous side effects. In order to investigate the structure–cytotoxicity relationship, AMI …