Biphalin, one of the opioid agonists, is a dimeric analog of enkephalin with a high affinity for
opioid receptors. Opioid receptors are widespread in the central nervous system and in …

Biphalin (Tyr-D-Ala-Gly-Phe-NH-NH<-Phe<-Gly<-D-Ala<-Tyr) is an opioid octapeptide with a
dimeric structure based on two identical pharmacophore portions, derived from enkephalins …

Natural residues of the dimeric opioid peptide Biphalin were replaced by the corresponding
homo-β3 amino acids. The derivative 1 containing hβ3 Phe in place of Phe showed good μ …

A novel bivalent opioid tetrapeptide, biphalin (Tyr-d-Ala-Gly-Phe-NH) 2, was synthesized
based on structure-activity relationships. The analgesic activity of biphalin was assessed in …

Biphalin, a synthetic opioid octapeptide with a palindromic sequence has high analgesic
activity. Biphalin displays a strong affinity for μ and δ-opioid receptors, and a significant to κ …

Biphalin is a linear octapeptide with strong opioid activity. Its structure is based on two
identical sequences derived from enkephalins joined C-terminal to C-terminal by an …

Biphalin is a potent opioid peptide agonist, with a palandromic structure, composed of two
enkephalin-like active fragments connected tail to tail by a hydrazine linker (Tyr-D-Ala-Gly …

Biphalin, is a palindromic peptide [(Tyr-D-Ala-Gly-Phe-NH-) 2] in which two opioid
pharmacophores are connected “tail-to-tail.” This peptide displays a broad affinity for all …

Among the many opioid peptides developed to date as nonaddictive analgesics, biphalin
has exhibited extraordinary high potency and many other desirable characteristics. Biphalin …

The synthesis and biological activity of two fragments of the very potent opioid peptide
biphalin, showed that Tyr-D-Ala-Gly-Phe-NH-NH<-Phe is the minimal fragment necessary to …