The chemical synthesis of modified oligoribonucleotides represents a powerful approach to
study the structure, stability, and biological activity of RNAs. Selected RNA modifications …

RNA plays a myriad of roles in the body including the coding, decoding, regulation, and
expression of genes. RNA oligonucleotides have garnered significant interest as …

Nowadays, RNA synthesis has become an essential tool not only in the field of molecular
biology and medicine, but also in areas like molecular diagnostics and material sciences …

While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

Conspectus Efforts to chemically modify nucleic acids got underway merely a decade after
the discovery of the DNA double helix and initially targeted nucleosides and nucleotides …

Oligonucleotides containing modified nucleobases have applications in various
technologies. In general, to synthesize oligonucleotides with different nucleobase structures …

As the knowledge of the biological functions of RNA expands, the demand for research tools
to investigate intracellular RNA is increasing. Oligonucleotides can be rationally designed …

Modified nucleotides are increasingly being utilized in all categories of therapeutic
oligonucleotides to increase nuclease-resistance, target affinity and specificity. The extent to …

An original post-synthetic method on a solid support was developed to introduce various
disulfide bond containing groups at the 2′-OH of oligoribonucleotides (RNAs). It is based …

Efficient methods for the covalent modification of large RNA molecules should find
significance utility as innovative biological tools as well as therapeutic methods. In this study …