Neurotropin attenuates local inflammatory response and inhibits demyelination induced by chronic constriction injury of the mouse sciatic nerve
S Nishimoto, K Okada, H Tanaka, M Okamoto… - Biologicals, 2016 - Elsevier
Neuropathic pain caused by nerve damage in the central and/or peripheral nervous systems
is a refractory disorder and the management of such chronic pain has become a major …
is a refractory disorder and the management of such chronic pain has become a major …
[HTML][HTML] Neurotropin® accelerates peripheral nerve regeneration in a rat sciatic nerve crush injury model
T Iwahashi, K Suzuki, H Tanaka, H Matsuoka… - Journal of Orthopaedic …, 2024 - Elsevier
Background Peripheral nerve injuries are common and serious conditions. The effect of
Neurotropin®(NTP), a nonprotein extract derived from the inflamed skin of rabbits inoculated …
Neurotropin®(NTP), a nonprotein extract derived from the inflamed skin of rabbits inoculated …
[HTML][HTML] Neurotropin inhibits neuroinflammation via suppressing NF-κB and MAPKs signaling pathways in lipopolysaccharide-stimulated BV2 cells
Y Zheng, W Fang, S Fan, W Liao, Y Xiong… - Journal of …, 2018 - Elsevier
Neurotropin (NTP) is a widely used drug in China and Japan mainly for the treatment of
chronic pain and peripheral inflammation. Nevertheless, the effects of NTP on …
chronic pain and peripheral inflammation. Nevertheless, the effects of NTP on …
Minocycline reduces the injury-induced expression of prodynorphin and pronociceptin in the dorsal root ganglion in a rat model of neuropathic pain
J Mika, E Rojewska, W Makuch, B Przewlocka - Neuroscience, 2010 - Elsevier
A role of neuropeptides in neuropathic pain development has been implicated; however, the
neuroimmune interactions that are involved in the underlying mechanisms may be more …
neuroimmune interactions that are involved in the underlying mechanisms may be more …
Neurotropin® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response
X Zhou, H Iida, Y Li, A Ota, L Zhuo… - Molecular …, 2024 - journals.sagepub.com
Background: Scar formation after trauma and surgery involves an inflammatory response
and can lead to the development of chronic pain. Neurotropin®(NTP) is a nonprotein extract …
and can lead to the development of chronic pain. Neurotropin®(NTP) is a nonprotein extract …
Effects of neurotropin on hyperalgesia and allodynia in mononeuropathic rats
MR Saleh, H Muneshige, Y Ikuta - Life Sciences, 1998 - Elsevier
Neurotropin is commonly used in Japan for the treatment of chronic pain. Using a rat model,
we evaluated the effect of neurotropin on a unilateral peripheral mononeuropathy produced …
we evaluated the effect of neurotropin on a unilateral peripheral mononeuropathy produced …
Excitatory effect of Neurotropin® on noradrenergic neurons in rat locus coeruleus
H Okai, R Okazaki, M Kawamura, M Yoshimura - Life sciences, 2015 - Elsevier
Aims Although the clinical use of Neurotropin® as an analgesic for chronic pain has been
firmly established, its analgesic mechanism is still unclear. In this study, we investigate the …
firmly established, its analgesic mechanism is still unclear. In this study, we investigate the …
The antiallodynic effect of neurotropin® is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation
R Okazaki, H Namba, H Yoshida, H Okai… - Anesthesia & …, 2008 - journals.lww.com
BACKGROUND: Neurotropin®, a nonprotein extract isolated from inflamed skin of rabbits
inoculated with vaccinia virus, is widely used in Japan to treat chronic pain such as …
inoculated with vaccinia virus, is widely used in Japan to treat chronic pain such as …
[HTML][HTML] Neurotropin exerts neuroprotective effects after spinal cord injury by inhibiting apoptosis and modulating cytokines
X Yao, C Sun, B Fan, C Zhao, Y Zhang, H Duan… - Journal of Orthopaedic …, 2021 - Elsevier
Background/objective Spinal cord injury (SCI) severely and irreversibly damages the central
nervous system. Neurotropin (NTP), a nonprotein extract obtained from inflamed rabbit skin …
nervous system. Neurotropin (NTP), a nonprotein extract obtained from inflamed rabbit skin …
Mechanisms of analgesic action of neurotropin on chronic pain in adjuvant-induced arthritic rat: roles of descending noradrenergic and serotonergic systems
T Miura, R Okazaki, H Yoshida, H Namba… - Journal of …, 2005 - Elsevier
Neurotropin®, a non-protein extract from the inflamed skin of rabbits inoculated with vaccinia
virus, has been clinically used as an analgesic drug for treatment of chronic pain. In this …
virus, has been clinically used as an analgesic drug for treatment of chronic pain. In this …