Investigating viral subversion of intercellular communication
PJ Calhoun II - 2020 - vtechworks.lib.vt.edu
Adenoviruses are non-enveloped, dsDNA tumor viruses responsible for a breadth of
pathogenesis including acute respiratory disease and viral myocarditis. Gap junctions …
pathogenesis including acute respiratory disease and viral myocarditis. Gap junctions …
[HTML][HTML] Adenovirus targets transcriptional and post-translational mechanisms to limit gap junction function
PJ Calhoun, AV Phan, JD Taylor… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Adenoviruses are responsible for a spectrum of pathogenesis including viral myocarditis.
The gap junction protein connexin43 (Cx43, gene name GJA1) facilitates rapid propagation …
The gap junction protein connexin43 (Cx43, gene name GJA1) facilitates rapid propagation …
Regulation of Cx43 GJ aggregation by ZO-1 potentially modulates differential adhesion between cardiac myocytes and fibroblasts
JM Rhett, J Jourdan, S Kidder, T Baudino, RG Gourdie - 2009 - Am Heart Assoc
Gap junctions (GJs) comprised of Cx43 have been linked to cardiac arrhythmia and infarct
size. Cx43 GJs have been reported to occur between myocytes and fibroblasts, though the …
size. Cx43 GJs have been reported to occur between myocytes and fibroblasts, though the …
[HTML][HTML] Autoregulation of connexin43 gap junction formation by internally translated isoforms
During each heartbeat, intercellular electrical coupling via connexin43 (Cx43) gap junctions
enables synchronous cardiac contraction. In failing hearts, impaired Cx43 trafficking reduces …
enables synchronous cardiac contraction. In failing hearts, impaired Cx43 trafficking reduces …
Heart ischemia gives a second life to Cx43: Novel roles ascribed to Cx43 that go beyond gap junction intercellular communication
TSM Marques - 2020 - estudogeral.uc.pt
A well-balanced intercellular communication between the different cells within the
myocardium is vital for the maintenance of cardiac homeostasis and function. In the heart …
myocardium is vital for the maintenance of cardiac homeostasis and function. In the heart …
[HTML][HTML] Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias
Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensures rapid action
potential propagation and synchronized heart contraction. Alterations in Cx43 localization …
potential propagation and synchronized heart contraction. Alterations in Cx43 localization …
Targeting Gap Junctions as a Mechanism and Potential Treatment of Cardiac Arrhythmias
M Strom - 2010 - rave.ohiolink.edu
Cardiac gap junctions play a critical role in intercellular communication, impulse conduction
and propagation. Gap junction remodeling and under expression are increasingly …
and propagation. Gap junction remodeling and under expression are increasingly …
Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells
Classically associated with gap junction-mediated intercellular communication, connexin43
(Cx43) is increasingly recognized to possess non-canonical biological functions, including …
(Cx43) is increasingly recognized to possess non-canonical biological functions, including …
Adenovirus increases arrhythmia susceptibility during acute cardiac infection
Myocarditis is responsible for 42% of sudden cardiac death in young adults, yet mechanisms
underlying virally induced arrhythmia remain elusive. Adenovirus is a leading etiological …
underlying virally induced arrhythmia remain elusive. Adenovirus is a leading etiological …
[HTML][HTML] Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes
T Martins-Marques, T Ribeiro-Rodrigues… - Life Science …, 2020 - life-science-alliance.org
Ischemic heart disease has been associated with an impairment on intercellular
communication mediated by both gap junctions and extracellular vesicles. We have …
communication mediated by both gap junctions and extracellular vesicles. We have …