Investigating viral subversion of intercellular communication

PJ Calhoun II - 2020 - vtechworks.lib.vt.edu
Adenoviruses are non-enveloped, dsDNA tumor viruses responsible for a breadth of
pathogenesis including acute respiratory disease and viral myocarditis. Gap junctions …

[HTML][HTML] Adenovirus targets transcriptional and post-translational mechanisms to limit gap junction function

PJ Calhoun, AV Phan, JD Taylor… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Adenoviruses are responsible for a spectrum of pathogenesis including viral myocarditis.
The gap junction protein connexin43 (Cx43, gene name GJA1) facilitates rapid propagation …

Regulation of Cx43 GJ aggregation by ZO-1 potentially modulates differential adhesion between cardiac myocytes and fibroblasts

JM Rhett, J Jourdan, S Kidder, T Baudino, RG Gourdie - 2009 - Am Heart Assoc
Gap junctions (GJs) comprised of Cx43 have been linked to cardiac arrhythmia and infarct
size. Cx43 GJs have been reported to occur between myocytes and fibroblasts, though the …

[HTML][HTML] Autoregulation of connexin43 gap junction formation by internally translated isoforms

JW Smyth, RM Shaw - Cell reports, 2013 - cell.com
During each heartbeat, intercellular electrical coupling via connexin43 (Cx43) gap junctions
enables synchronous cardiac contraction. In failing hearts, impaired Cx43 trafficking reduces …

Heart ischemia gives a second life to Cx43: Novel roles ascribed to Cx43 that go beyond gap junction intercellular communication

TSM Marques - 2020 - estudogeral.uc.pt
A well-balanced intercellular communication between the different cells within the
myocardium is vital for the maintenance of cardiac homeostasis and function. In the heart …

[HTML][HTML] Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias

S Xiao, D Shimura, R Baum… - The Journal of …, 2020 - Am Soc Clin Investig
Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensures rapid action
potential propagation and synchronized heart contraction. Alterations in Cx43 localization …

Targeting Gap Junctions as a Mechanism and Potential Treatment of Cardiac Arrhythmias

M Strom - 2010 - rave.ohiolink.edu
Cardiac gap junctions play a critical role in intercellular communication, impulse conduction
and propagation. Gap junction remodeling and under expression are increasingly …

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

T Martins-Marques, K Witschas, I Ribeiro… - Open …, 2023 - royalsocietypublishing.org
Classically associated with gap junction-mediated intercellular communication, connexin43
(Cx43) is increasingly recognized to possess non-canonical biological functions, including …

Adenovirus increases arrhythmia susceptibility during acute cardiac infection

RL Padget, GA Blair, MD North, DR King… - The FASEB …, 2022 - Wiley Online Library
Myocarditis is responsible for 42% of sudden cardiac death in young adults, yet mechanisms
underlying virally induced arrhythmia remain elusive. Adenovirus is a leading etiological …

[HTML][HTML] Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

T Martins-Marques, T Ribeiro-Rodrigues… - Life Science …, 2020 - life-science-alliance.org
Ischemic heart disease has been associated with an impairment on intercellular
communication mediated by both gap junctions and extracellular vesicles. We have …