Introduction: Melatonin is a neurohormone that controls many relevant physiological
processes beyond the control of circadian rhythms. Melatonin's actions are carried out by …

Melatonin is primarily synthesized and secreted by the pineal gland during darkness in a
normal diurnal cycle. In addition to its intrinsic antioxidant property, the neurohormone has …

Melatonin is a neurohormone that translates the circadian rhythm to the peripheral organs
through a series of binding sites identified as G protein‐coupled receptors MT1 and MT2 …

The neurohormone melatonin is involved in the regulation of many physiological functions,
in particular those related to circadian and seasonal rhythms. In mammals, melatonin …

Importance of the field: Increasing clinical evidences suggest that melatonin receptor
agonists can represent a novel therapeutic approach for the treatment of sleep disturbances …

The tryptophan derivative melatonin is an evolutionary old molecule that is involved in a
pleiotropy of physiological functions. In humans, age‐related decline of circulating melatonin …

Melatonin receptors have been studied for several decades. The low expression of the
receptors in tissues led the scientific community to find a substitute for the natural hormone …

Melatonin exerts many of its actions through the activation of two G protein-coupled
receptors (GPCRs), named MT1 and MT2. So far, a number of different MT1 and MT2 …

The third melatonin binding site, MT3 is a non-classical one since it is not a seven
transmembrane domains receptor, but an enzyme, quinone reductase 2. A major concern for …

The search for melatonin receptor agonists and antagonists specific towards one of the
receptor subtypes will extend our understanding of the role of this system in relaying …