Multifaceted Alzheimer's disease: Building a roadmap for advancement of novel therapies

D Kaur, T Behl, A Sehgal, S Singh, N Sharma… - Neurochemical …, 2021 - Springer
Alzheimer's disease (AD) is one of the most prevailing neurodegenerative disorders of
elderly humans associated with cognitive damage. Biochemical, epigenetic, and …

Recent advances in the multitarget‐directed ligands approach for the treatment of Alzheimer's disease

R Leon, AG Garcia… - Medicinal research …, 2013 - Wiley Online Library
With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

[HTML][HTML] Multi-targets: An unconventional drug development strategy for Alzheimer's disease

CX Gong, CL Dai, F Liu, K Iqbal - Frontiers in aging neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that eventually leads
to dementia and death of the patient. Despite the enormous amounts of resources and …

Multitarget directed ligand approaches for Alzheimer's disease: A Comprehensive Review

N Ramalakshmi, R RS, N CN - Mini Reviews in Medicinal …, 2021 - ingentaconnect.com
Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative disease, and a
drug which targets a single protein would not provide a cure for this disease. Currently …

The multifactorial nature of Alzheimer's disease for developing potential therapeutics

M Carmo Carreiras, E Mendes… - Current topics in …, 2013 - ingentaconnect.com
Alzheimerβs disease (AD) is a multifactorial neurodegenerative disorder with several target
proteins contributing to its aetiology. Pathological, genetic, biochemical, and modeling …

[HTML][HTML] Clinical relevance of biomarkers, new therapeutic approaches, and role of post-translational modifications in the pathogenesis of Alzheimer's disease

I Mumtaz, MO Ayaz, MS Khan, U Manzoor… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder that causes progressive loss of
cognitive functions like thinking, memory, reasoning, behavioral abilities, and social skills …

Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment?

A Rampa, S Gobbi, F Belluti… - Current Topics in Medicinal …, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain
associated with memory impairment, progressive cognitive decline and changes in …

[HTML][HTML] Perspective insights into disease progression, diagnostics, and therapeutic approaches in Alzheimer's disease: a judicious update

AT Jan, M Azam, S Rahman, AMS Almigeiti… - Frontiers in aging …, 2017 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive
accumulation of β-amyloid fibrils and abnormal tau proteins in and outside of neurons …

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …

Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development

BP Dave, YB Shah, KG Maheshwari… - Cellular and Molecular …, 2023 - Springer
Alzheimer's disease (AD) is the primary cause of dementia and is characterized by the death
of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of …