Perspectives for new and more efficient multifunctional ligands for Alzheimer′ s disease therapy

A Zagórska, A Jaromin - Molecules, 2020 - mdpi.com
Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …

Beyond the classical amyloid hypothesis in Alzheimer's disease: Molecular insights into current concepts of pathogenesis, therapeutic targets, and study models

A Theerasri, S Janpaijit, T Tencomnao… - WIREs Mechanisms …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is one of the progressive neurodegenerative disorders and the
most common cause of dementia in the elderly worldwide causing difficulties in the daily life …

Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease

A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …

[HTML][HTML] Alzheimer's disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs

AR Monteiro, DJ Barbosa, F Remião, R Silva - Biochemical Pharmacology, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that
affect millions of people worldwide, with both prevalence and incidence increasing with age …

Developments with multi-target drugs for Alzheimer's disease: An overview of the current discovery approaches

JF González, AR Alcántara, AL Doadrio… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Alzheimer's disease (AD), the most common type of dementia among older
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …

Alzheimer's disease: a systemic review of substantial therapeutic targets and the leading multi-functional molecules

T Umar, N Hoda - Current Topics in Medicinal Chemistry, 2017 - ingentaconnect.com
Alzheimer's Disease (AD) is a fatal neurodegenerative disorder, having a complex aetiology
with numerous possible drug targets. There are targets that have been known for years …

Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update

M de Freitas Silva, KST Dias, VS Gontijo… - Current Medicinal …, 2018 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands

L Blaikie, G Kay, PKT Lin - MedChemComm, 2019 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major
cause of death worldwide. The number of people suffering from this debilitating disorder is …

Designing multi-targeted therapeutics for the treatment of Alzheimer's disease

I Erdogan Orhan, F Sezer Senol - Current topics in medicinal …, 2016 - ingentaconnect.com
Due to multi-faceted pathology of AD; no drug can seize the progress of the disease,
whereas only the symptomatic treatment is available at the moment. Several drug classes to …

From combinations to multitarget‐directed ligands: A continuum in Alzheimer's disease polypharmacology

C Albertini, A Salerno… - Medicinal Research …, 2021 - Wiley Online Library
The continued drug discovery failures in complex neurodegenerative diseases, including
Alzheimer's disease (AD), has raised questions about the classical paradigm “one‐drug …