Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus

K Yang, Y Shadkchan, J Tannous… - Virulence, 2018 - Taylor & Francis
The ubiquitous fungus Aspergillus flavus is notorious for contaminating many important
crops and food-stuffs with the carcinogenic mycotoxin, aflatoxin. This fungus is also the …

The Aspergillus fumigatus transcription factor AceA is involved not only in Cu but also in Zn detoxification through regulating transporters CrpA and ZrcA

Z Cai, W Du, Z Zhang, L Guan, Q Zeng… - Cellular …, 2018 - Wiley Online Library
Abstract Copper (Cu) and zinc (Zn) are essential nutrients for both pathogens and hosts;
however, their excess accumulation is toxic for all cells. The Aspergillus transcription factor …

Heavy Metal-Induced Expression of PcaA Provides Cadmium Tolerance to Aspergillus fumigatus and Supports Its Virulence in the Galleria mellonella Model

F Bakti, C Sasse, T Heinekamp, I Pócsi… - Frontiers in …, 2018 - frontiersin.org
Most of the metal transporters in Aspergillus fumigatus are yet uncharacterized. Their role in
fungal metabolism and virulence remains unclear. This paper describes the novel P IB-type …

Transcriptional response of Aspergillus fumigatus to copper and the role of the Cu chaperones

D Anabosi, Z Meir, Y Shadkchan, M Handelman… - Virulence, 2021 - Taylor & Francis
Aspergillus fumigatus is the leading cause of life-threatening invasive mold infections in
immunocompromised individuals. This ubiquitous saprophyte possesses several natural …

Cu-sensing transcription factor Mac1 coordinates with the Ctr transporter family to regulate Cu acquisition and virulence in Aspergillus fumigatus

Z Cai, W Du, Q Zeng, N Long, C Dai, L Lu - Fungal Genetics and Biology, 2017 - Elsevier
Copper (Cu) is an essential trace element and is regarded as an important virulence factor
in fungal pathogens. Previous studies suggest that a putative Cu-sensing transcription factor …

Ambient Availability of Amino Acids, Proteins, and Iron Impacts Copper Resistance of Aspergillus fumigatus

A Yap, H Talasz, H Lindner, R Würzner… - Frontiers in Cellular and …, 2022 - frontiersin.org
The transition metals iron and copper are required by virtually all organisms but are toxic in
excess. Acquisition of both metals and resistance to copper excess have previously been …

Cu transporter protein CrpF protects against Cu-induced toxicity in Fusarium oxysporum

D Lorenzo-Gutiérrez, L Gómez-Gil, J Guarro… - Virulence, 2020 - Taylor & Francis
Cu is an essential trace element for cell growth and proliferation. However, excess of Cu
accumulation leads to cellular toxicity. Thus, precise and tight regulation of Cu homeostasis …

Transcription factor Afmac1 controls copper import machinery in Aspergillus fumigatus

Y Kusuya, D Hagiwara, K Sakai, T Yaguchi, T Gonoi… - Current Genetics, 2017 - Springer
Copper (Cu) is an essential metal for all living organisms, although it is toxic in excess.
Filamentous fungus must acquire copper from its environment for growth. Despite its …

The Role of Zinc in Copper Homeostasis of Aspergillus fumigatus

S Kang, H Seo, HS Moon, JH Kwon, YS Park… - International journal of …, 2020 - mdpi.com
Copper is an essential metal ion that performs many physiological functions in living
organisms. Deletion of Afmac1, which is a copper-responsive transcriptional activator in A …

Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus

N Raffa, N Osherov, NP Keller - International Journal of Molecular …, 2019 - mdpi.com
Copper is an essential micronutrient for the opportunistic human pathogen, Aspergillus
fumigatus. Maintaining copper homeostasis is critical for survival and pathogenesis. Copper …