C66 and B2brbc Modulate Oxidative Stress, Jnk Activity, and Pancreatic Gene Expression In Rats with Streptozotocin-Induced Diabetes

R Stojchevski, S Velichkovikj, J Bogdanov… - Jnk Activity, and … - papers.ssrn.com
Introduction: The pathogenesis of type 1 diabetes mellitus (T1DM) involves oxidative stress
and inflammation. Curcumin, a natural polyphenolic compound found in turmeric, with …

557-P: Effect of monocarbonyl curcumin analogues C66 and B2BrBC on pancreatic expression of genes related to insulin signaling pathway and oxidative stress in …

R Stojchevski, M Angelovski, S Velichkovikj… - Diabetes, 2022 - Am Diabetes Assoc
Curcumin has well documented beneficial effects against diabetes but its poor bioavailability
limits its use. Here, we investigated the effects of two monocarbonyl curcumin analogues …

1807-PUB: Monocarbonyl Curcumin Analogs C66 and B2BrBC Improve Redox Status in Streptozotocin-Induced Diabetic Rats

R STOJCHEVSKI, M ANGELOVSKI… - Diabetes, 2023 - Am Diabetes Assoc
Curcumin is a natural polyphenolic compound with recognized antioxidant and anti-
inflammatory effects. However, low water solubility, poor bioavailability, and rapid …

NF‐κB pathway as a molecular target for curcumin in diabetes mellitus treatment: Focusing on oxidative stress and inflammation

MY Zamanian, HO Alsaab… - Cell Biochemistry …, 2024 - Wiley Online Library
Diabetes mellitus (DM) is a collection of metabolic disorder that is characterized by chronic
hyperglycemia. Recent studies have demonstrated the crucial involvement of oxidative …

Attenuation of high-glucose-induced inflammatory response by a novel curcumin derivative B06 contributes to its protection from diabetic pathogenic changes in rat …

Y Pan, G Zhu, Y Wang, L Cai, Y Cai, J Hu, Y Li… - The Journal of nutritional …, 2013 - Elsevier
There is increasing evidence indicating that inflammatory processes are involved in the
development and progression of diabetic complications. However, effective anti …

Curcumin analogs reduce stress and inflammation indices in experimental models of diabetes

S Biswas, S Chen, G Liang, B Feng, L Cai… - Frontiers in …, 2019 - frontiersin.org
Chronic inflammation and oxidative stress lead to a multitude of adverse cellular responses
in target organs of chronic diabetic complications. Curcumin, a highly investigated …

Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications

B Meng, J Li, H Cao - Current pharmaceutical design, 2013 - ingentaconnect.com
Diabetes mellitus (DM) has reached pandemic status and shows no signs of abatement. It
can severely impair people's quality of life and affects patients all over the world. Since it is a …

Therapeutic Potential of Curcumin, a Bioactive Compound of Turmeric, in Prevention of Streptozotocin-Induced Diabetes through the Modulation of Oxidative Stress …

AK Alsulaim, TH Almutaz, AA Albati, AH Rahmani - Molecules, 2023 - mdpi.com
This study evaluates the anti-diabetic potential and underlying mechanisms of curcumin in
streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats. The rats were randomly …

How curcumin targets inflammatory mediators in diabetes: therapeutic insights and possible solutions

Y Hussain, H Khan, G Alotaibi, F Khan, W Alam… - Molecules, 2022 - mdpi.com
Diabetes mellitus is a multifactorial chronic metabolic disorder, characterized by altered
metabolism of macro-nutrients, such as fats, proteins, and carbohydrates. Diabetic …

[HTML][HTML] Curcumin alleviates liver oxidative stress in type 1 diabetic rats

Z Xie, B Wu, G Shen, X Li, Q Wu - Molecular medicine …, 2018 - spandidos-publications.com
The aim of the present study was to determine the effects of curcumin on antioxidants using
a rat model of type 1 diabetes. Seven‑week‑old male Sprague‑Dawley rats were injected …