Evolution of treatments for patients with acute lung injury

AM Esper, GS Martin - Expert Opinion on Investigational Drugs, 2005 - Taylor & Francis
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are acute life-
threatening forms of hypoxemic respiratory failure. ALI/ARDS patients require intensive care …

Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome

KJ Bosma, JF Lewis - Expert Opinion on Emerging Drugs, 2007 - Taylor & Francis
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a life-threatening form of
respiratory failure that affects a heterogeneous population of critically ill patients. Although …

Surfactant therapy for acute lung injury/acute respiratory distress syndrome

JJ Haitsma, PJ Papadakos… - Current opinion in critical …, 2004 - journals.lww.com
Surfactant therapy for acute lung injury/acute respiratory d... : Current Opinion in Critical
Care Surfactant therapy for acute lung injury/acute respiratory distress syndrome : Current …

Emerging drugs for acute lung injury

D Impellizzeri, G Bruschetta, E Esposito… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Acute respiratory distress syndromes (ARDS) are devastating disorders of
overwhelming pulmonary inflammation and hypoxemia, resulting in high morbidity and …

The future of surfactant therapy during ALI/ARDS

JF Lewis, RAW Veldhuizen - Seminars in respiratory and …, 2006 - thieme-connect.com
The importance of pulmonary surfactant in maintaining normal lung function, and the
observations that alterations in endogenous surfactant contribute to the lung dysfunction …

Pharmacology of acute lung injury

S Tasaka, N Hasegawa, A Ishizaka - Pulmonary pharmacology & …, 2002 - Elsevier
The acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a clinical
syndrome that affects both medical and surgical patients. To date, despite improved …

Role of exogenous surfactant in acute lung injury

JF Lewis, A Brackenbury - Critical care medicine, 2003 - journals.lww.com
Objectives To outline both the preclinical and clinical data demonstrating surfactant
alterations in acute lung injury, which provide the rationale for testing exogenous surfactant …

Randomized clinical trial of activated protein C for the treatment of acute lung injury

KD Liu, J Levitt, H Zhuo, RH Kallet, S Brady… - American journal of …, 2008 - atsjournals.org
Rationale: Microvascular injury, inflammation, and coagulation play critical roles in the
pathogenesis of acute lung injury (ALI). Plasma protein C levels are decreased in patients …

Pharmacotherapy for prevention and treatment of acute respiratory distress syndrome: current and experimental approaches

KJ Bosma, R Taneja, JF Lewis - Drugs, 2010 - Springer
The acute respiratory distress syndrome (ARDS) arises from direct and indirect injury to the
lungs and results in a life-threatening form of respiratory failure in a heterogeneous, critically …

Clinical developments for treating ARDS

G Martin, S Eaton - Expert Opinion on Investigational Drugs, 2002 - Taylor & Francis
Acute respiratory distress syndrome (ARDS), is characterised by capillary permeability and
pulmonary oedema formation and may complicate a variety of medical and surgical …