Chemogenetic activation of endogenous arginine vasopressin exerts anorexigenic effects via central nesfatin-1/NucB2 pathway

K Sanada, M Yoshimura, N Ikeda, K Baba… - The Journal of …, 2021 - Springer
We examined whether the chemogenetic activation of endogenous arginine vasopressin
(AVP) affects central nesfatin-1/NucB2 neurons, using a transgenic rat line that was …

The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist

GLC Yosten, WK Samson - American Journal of Physiology …, 2010 - journals.physiology.org
Nesfatin-1 is an 82-amino acid protein encoded by the nucleobindin2 gene. When injected
intracerebroventricularly, nesfatin-1, via a melanocortin ¾ receptor-dependent mechanism …

A role of nesfatin-1/NucB2 in dehydration-induced anorexia

M Yoshimura, T Matsuura, J Ohkubo… - American Journal …, 2014 - journals.physiology.org
Nesfatin-1/NucB2, an anorexigenic molecule, is expressed mainly in the hypothalamus,
particularly in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN). Nesfatin …

Localization of nesfatin-1 neurons in the mouse brain and functional implication

M Goebel-Stengel, L Wang, A Stengel, Y Taché - Brain research, 2011 - Elsevier
Nesfatin-1 reduces food intake when injected centrally in rodents. We recently described
wide distribution of nucleobindin2 (NUCB2)/nesfatin-1 immunoreactivity in rat brain …

Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding

D Kohno, M Nakata, Y Maejima, H Shimizu… - …, 2008 - academic.oup.com
Nesfatin-1, a newly discovered satiety molecule, is located in the hypothalamic nuclei,
including the paraventricular nucleus (PVN) and supraoptic nucleus (SON). In this study, fine …

[PDF][PDF] Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway

Y Maejima, U Sedbazar, S Suyama, D Kohno, T Onaka… - Cell metabolism, 2009 - cell.com
The hypothalamic paraventricular nucleus (PVN) functions as a center to integrate various
neuronal activities for regulating feeding behavior. Nesfatin-1, a recently discovered …

Involvement of central nesfatin-1 neurons on oxytocin-induced feeding suppression in rats

R Saito, S Sonoda, H Ueno, Y Motojima… - Neuroscience …, 2017 - Elsevier
Peripheral anorectic hormones, such as peptide YY (PYY) and oxytocin (OXT), suppress
food intake. A newly identified anorectic neuropeptide, nesfatin-1, is synthesized in both …

Central Nesfatin-1 Reduces Dark-Phase Food Intake and Gastric Emptying in Rats: Differential Role of Corticotropin-Releasing Factor2 Receptor

A Stengel, M Goebel, L Wang, J Rivier, P Kobelt… - …, 2009 - academic.oup.com
Nesfatin-1, derived from nucleobindin2, is expressed in the hypothalamus and reported in
one study to reduce food intake (FI) in rats. To characterize the central anorexigenic action of …

Nesfatin-1 influences the excitability of glucosensing neurons in the dorsal vagal complex and inhibits food intake

J Dong, HZ Guan, ZY Jiang, X Chen - PLoS One, 2014 - journals.plos.org
Nesfatin-1 is a recently discovered metabolic peptide hormone that decreases food intake
after lateral, third, or fourth brain ventricle; cisterna magna; or paraventricular nucleus (PVN) …

Increased blood pressure in nesfatin/nuclebindin-2-transgenic mice

Y Mori, H Shimizu, H Kushima, M Hiromura… - Hypertension …, 2017 - nature.com
Abstract Nesfatin/nucleobindin-2 (nesf/NUCB2), a precursor of the anorexigenic protein
nesfatin-1, is selectively expressed in the hypothalamic nuclei, which are central to the …