Loss of dystrophin leads to Duchenne muscular dystrophy (DMD). A pathogenic feature of
DMD is the significant elevation of cytosolic calcium. Supraphysiological calcium triggers …

Background Cardiomyocyte calcium overloading has been implicated in the pathogenesis of
Duchenne muscular dystrophy (DMD) heart disease. The cardiac isoform of sarcoplasmic …

Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders
characterized by progressive muscle wasting and often premature death. The primary defect …

Background The BIO14. 6 hamster is an excellent animal model for inherited
cardiomyopathy, because of its lethal and well-documented course, due to a spontaneous …

Although the precise pathophysiological mechanism of muscle damage in dystrophin-
deficient muscle remains disputed, calcium appears to be a critical mediator of the …

Background Duchenne muscular dystrophy (DMD) is an X-linked inherited disease caused
by mutations in the gene encoding dystrophin that leads to a severe and ultimately life …

Duchenne muscular dystrophy (DMD) is a fatal genetic disease caused by the absence of
the sarcolemmal protein dystrophin. Dilated cardiomyopathy leading to heart failure is a …

Duchenne muscular dystrophy (DMD) is the most common form of the progressive muscular
dystrophies characterized by defects of the dystrophin gene. Although primarily …

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting
secondary to repeated muscle damage and inadequate repair. Elevations in intracellular …

Background Cardiomyopathy is a leading health threat in Duchenne muscular dystrophy
(DMD). Cytosolic calcium upregulation is implicated in DMD cardiomyopathy. Calcium is …