In heart, glucose and glycolysis are important for anaplerosis and potentially therefore for d‐
β‐hydroxybutyrate (βHB) oxidation. As a glucose store, glycogen may also furnish …

Abbreviations: AcAc, acetoacetate; AcAc-CoA, acetoacetyl-CoA; ADP, adenosine
diphosphate; ATP, adenosine triphosphate; βHB, beta-hydroxybutyrate; C, carbon; CO2 …

Aims Ketones have been proposed to be a 'thrifty'fuel for the heart and increasing cardiac
ketone oxidation can be cardioprotective. However, it is unclear how much ketone oxidation …

Aims The failing heart is energy-starved and inefficient due to perturbations in energy
metabolism. Although ketone oxidation has been shown recently to increase in the failing …

The ketone bodies, d-β-hydroxybutyrate and acetoacetate, are soluble 4-carbon compounds
derived principally from fatty acids, that can be metabolised by many oxidative tissues …

The high energy demands of the heart are met primarily by the mitochondrial oxidation of
fatty acids and glucose. However, in heart failure there is a decrease in cardiac …

Background—The failing human heart is characterized by metabolic abnormalities, but
these defects remains incompletely understood. In animal models of heart failure there is a …

Growing evidence suggests that the utilization of ketone bodies increases in the heart during
hypertrophy and heart failure; however, how the increased utilization of ketone bodies …

Extrahepatic tissues which oxidise ketone bodies also have the capacity to accumulate them
under particular conditions. We hypothesised that acetyl-coenzyme A (acetyl-CoA) …

Background—Significant evidence indicates that the failing heart is energy starved. During
the development of heart failure, the capacity of the heart to utilize fatty acids, the chief fuel …