Cyclic intermittent hypoxia (IH) increases cerebral blood velocity. This enhanced velocity
augments the commensurate shear stimulus and may subsequently increase …

This study aimed to elucidate the effect of aging on shear-mediated dilation of the common
and internal carotid arteries (CCA and ICA, respectively). Hypercapnia-induced shear …

Evidence for shear stress as a regulator of carotid artery dilation in response to increased
arterial CO2 was recently demonstrated in humans during sustained elevations in CO2 …

Increases in arterial carbon dioxide tension (hypercapnia) elicit potent vasodilation of
cerebral arterioles. Recent studies have also reported vasodilation of the internal carotid …

New Findings• What is the central question of this study? Does hypoxia enhance blood flow
to all parts of the brain uniformly?• What is the main finding and its importance? During …

Intermittent (IH), as opposed to continuous hypoxia (CH), is thought to have beneficial effects
on cardiovascular function and health. In the present study, we examined the acute effects of …

Favourable patterns of shear stress, the coplanar deformation force acting on the luminal
surface 33 of blood vessel walls by the movement of blood, are known to produce peripheral …

The mechanistic role of arterial shear stress in the regulation of cerebrovascular responses
to physiological stimuli (exercise and hypercapnia) is poorly understood. We hypothesised …

Key points Brachial artery (BA) shear‐mediated dilatation is a widely used assessment of
vascular function with links to coronary artery health and cardiovascular risk. Cerebral …

Ischemic stroke (IS) induces neurological damage due to cerebrovascular occlusion.
Restoring blood perfusion to the ischemic brain area in a timely fashion is the most effective …